Fu Yang Jiedu Granule And Research On The Influence Of The Objective Indicators Hiv Asymptomatic Period

Objective:1、To explore the process of Fu Yang detoxification prescriptions which is the best technology and quality control standards;2、To observe the Immune enhancing effects,the strong effect and anti-inflammatory effects with Animal model;,3、To observe of Fu Yang detoxification particle anti-HIV virus and increase the role of CD4lymphocytes in clinical.Method to set the appropriate process:according to characteristics of herbs in Fu Yang detoxification particle prescription to set the process,and to elect the process which is stable, quality and reliablthe with the determination of baicalin and the identify of Thin layer of herbs;Cyclophosphamide-induced immune suppression and physical weakness at mice, and then, to observe the Immune enhancing effects and the strong effect of Fu Yang detoxification particles on mice model.To observe the Anti-inflammatory effects with the mice their ears was Swelling at the Stimulating of Xylene; To researching the antiviral the activity and effecting of elevating the role of CD4cells in1year by Selecting72cases of HIV infection who is in Asymptomatic period.Results:Pharmacy and pharmacology results:By three determination, It is find that Baicalin content is basically the same,and the reproducibility of Scutellaria,barbata,and are fine. The comparing of the large doses and medium dose of Fu Yang detoxification particle with the mice model of Weak constitution by Cyclophosphamide show that the degree of absorption increased is significantly (p <0.05).The weight is Extremely significant according to the large doses and he mice model of Weak constitution by Cyclophosphamide (p<0.05);And the weight of Thymus is Increase by the comparing of the large doses and medium dose and models (p<0.05);The comparing of large doses of Fu Yang detoxification particles and mice auricular swelling model induced by xylene show that reduction of swelling is significant reduction of swelling (p<0.05). The results of clinical trials:The comparing of3,6,9,12month of viral load and before treatment was statistically significant (p<0.01), After the treatment of1year by Fu Yang detoxification particles, the reduction of the viral load in the effective rate is62.1%,and thestable rate is20.7%; The comparing of CD4of after treatment and before treatment were not statistically significant (P>0.05), After the treatment of1year by Fu Yang detoxification particles, the increasing of the CD4in the effective rate of is35.4%,and thestable rate is50.0%;Conclusion:The particle formulation process of Fu Yang detoxification prescriptions is stable,and the quality control standards can achieve quality-controled purposes.; Fu Yang detoxification particles have a certain degree of immune enhancement ithe strong role and anti-inflammatory effects in mice; Fu Yang detoxification particles have the effect of antiviral activity increasing CD4at the Asymptomatic period of HIV infection.