The Study Of PreParation Of Osthole Aquogel Suppository

Fructus Cnidii is the dry mature fruit in Cnidium monnieri (L.) Cuss. The fruits of Fructus Cnidii contained many kinds of chemical constituents, primarily including coumarins, chromones, benzofurans, glucides, etc. In the pharmacological aspects, the fruits had the effects on the cardiovascular system, the respiratory system, the immune system as well as the nervous system,they also had antiviral and antimutagenic. The studay to the active components of Fructus Cnidii concentrated on coumarins, especially osthole in Fructus Cnidii.According to Fructus Cnidii’s each biological activity, used for within and without, Studies and screens the strong effect new medicine and new dosage form to have the important meaning. This article mainly carries on the traditional Fructus Cnidii s extraction, the osthole hydrogel hitch the preparation craft, the quality research as well as in vitro release inspect.Take the active constituent osthole’s content as a target, uses in the HPLC method determination content of osthole in Fructus Cnidii, has carried on the confirmation experiment to the Fructus Cnidii’s extraction process, has determined the related extraction process parameter.Uses the orthogonal design to carry on to osthole Aquogel Suppository’s optimal prescription, determine carbomer for the Aquogel substrate, combine the freeze drying method to prepare Suppository, and established its content determination method. The results showed the content of osthole in the prescription was determined by HPLC method. And the method has good reproducibility, high precision, and can be used as quality standard of osthole content in the prescription.Inspected the osthole Aquogel Suppository’s in vitro release. According to vagina medication in vivo characteristic, consulted the first law which in Chp.2010, the osthole Aquogel Suppository dissolution rate was measured by the rotary basket method, and has established this Aquogel Suppository’s in vitro release’s determination method. This Aquogel Suppository can obviously lengthen the medicine the resident time, has the good slow release effect, meets the suppositories requirement and the characteristic.This research’s significance lay in for the Fructus Cnidii establishes one kind to have the good slow release effect,the suitable cavity road to give medicine the new dosage-form and the preparation craft. It both reduced for the medicine number of times, enhanced the curative effect,and has developed the suppositories application scope. Is advantageous in treats the vigorous sickness which vaginitis this kind of need applies drugs repeatedly for a long time.