Synthesis Of Pyrroloquinolins And Arylhydrazides Via Transition Metal Catalyst

This thesis includes two parts as the following:1. A new and efficient protocol for straight-forward synthesis of3H-pyrrolo[2,3-c]quinolin-4(5H)-ones derivatives by palladium-catalyzed sequentialcoupling/cyclization reactions has been developed.The key strategy relies on creation ofpyrrole ring through transition metal palladium-catalyzed intramolecular hydro-aminationof related acetylenic aminoquinolins.2. Transition metal Iron(III) chloride catalyzed direct amination of electron-richarenes with azodicarboxylates is disclosed, which generates the aryl hydrazides withmoderate to good yields in two minutes under mild conditions. This methodology willserve as an important tool for synthesis of biologically active nitrogen-containedproducts and pharmaceuticals.