Investigation On Synthesis Of The New Heterocyclic Compounds Based On Quinoline-2-one

Quinoline-2-one and its derivatives are found in many natural products as a veryimportant family of heterocyclic compounds, and exhibit various pharmacological andphysiological activities. Particularly, those containing one or two heteroatoms fused to aquinoline ring have been popular targets of synthesis due to their well-known potentantibacterial activity.This paper “Investigation on Synthesis of the new heterocyclic compounds Based onquinoline-2-one” related content consists of the following four parts:In the first part, the recent advance on the synthesis, activity, applications ofquinoline-2-one and its derivatives were reviewed on the basis of the survey of the relevanta large number of literature.In the second part, we used1-methyl-3-acetyl-4-hydroxyquinoline-2-one as rawmaterial for the synthesis of quinolin[4,3-b]pyran-4,5-dione derivatives underwentoxidative cyclization of1-methyl-3-cinnamoyl-4-hydroxyquinoline-2-one, synthesizedfrom condensation between1-methyl-3-acetyl-4-hydroxyquinoline-2-one with aromaticaldehydes in the presence of piperidine, by using iodine in I2-DMSO has been described.In the third part, we used1-methyl-3-acetyl-4-hydroxyquinoline-2-one as rawmaterial for the synthesis of furan[3,2-c]quinoline-3,4-dione derivatives underwentcyclization of1-methyl-3-bromineacetyl-4-hydroxyquinoline-2-one, synthesized fromcondensation between1-methyl-3-acetyl-4-hydroxyquinoline-2-one with bromide, byusing aromatic aldehydes has been described.In the fourth part, with4-brominemethyl quinoline-2-one as reaction raw materials forthe synthesis of benzene[b]benzofruan[2,3-e][1,6]naphthyridine-8-one derivativesunderwent cyclization of4-(3-aminobenzofuran)quinoline-2-one, synthesized fromcondensation between4-bromomethylquinoline-2-one with salicylic nitrile, by usingaromatic aldehydes has been described in the presence of trifluoroacetic acid.The structures of all compounds were characterized by IR,1H-NMR spectrum.