Research On Apheresis Principles Of Automatic Blood Seperator And Centrifugal Mechanism Design

With the development of medical technology, injection of blood component isnow widely uesd in clinic to treatment patients. Traditionally, component bloodproduction is produced more by manual methods. Some significant problems existwith this method in the nurse labor intensity and operation steps, meanwhile, themedical staff’s personal operation habit has a great influence on the quality ofcomponent blood. In order to improve the quality of the component blood and theefficiency of separation, the automatic blood cell separator is proposed. The uniqueblood channel and collection chamber need to be applied to the operation of bloodcell separator. Continuous blood circulation can be realized by the belt typeseparation channel, which has great advantage in seperation efficiency. Therefore,the apheresis principles of whole belt type separation channel is poprosed, then theseparation parameters is analyzed and the collection process with different bloodcomponent is designed. This provides basis for the future design of the automaticblood cell separator.Firstly, the composition and the movement principle of whole blood in the belttype separation channel is analyzed. The mechanics model of blood separationprocess is established in this thesis. Then, the laminar flow hypothesis which formsthe basis of the separation of the whole blood is proposed. According to the StocksLaw, the blood component subsidence coeffient is derived. In addition, in order todesign the separator, the factors that influence the blood centrifugal separation andthe methods to adjust the collection interface are analyzed.Secondly, according to the models of the belt type separation channel, thenumerical simulation of whole blood centrifugal separation process is accomplishedwith FLUENT. Different factors that influence the separating efficiency is studied,such as channel port structures, centrifugal rotational speed and collecting speed ofdifferent pipes. These parameters are used to design the process parameters of theblood cell separator.Thirdly, according to the theoretical analysis and simulation results, the processparameters setting and calculation for different collection processes are studiedbased on the classification of different apheresis. Meanwhile, taking security intoaccount, safety parameters are designed to make sure the comforts of donors. Thespeed gradient management is also designed for the speed of centrifuge, collection,and returnings to fufill different operating conditions, which is the basis of separatorcontrol system. Finally, a centrifugal structure is designed based on the previous analysis ofblood cells separation. In order to ensure the steady of blood separation and highcollecting speed, dynamic balance is considered and designed.