A Study Of Randomized Controlled Clinical Of Lamotrigine Against Late Epilepsy Of Injury

ObjectiveStudy on the effect of lamotrigine on preventing early epileptic seizure in patients with brain injury.MethodsSelect108patients of neurology department of HUA XI Hospital from January to December of2011. They are randomly divided into groups of A, B, C, and each group has36cases. The group A takes lamotrigine for3months, and group B takes lamotrigine for1month, and group C takes sodium valproate. All of the patients take medication in7days when they get the traumatic brain injury. The patients with unconsciousness require the implementation of nasogastric feeding. At last, the implementation of the12months followed up to108patients. It needs to record the numbers of people of early onset and late onset and the MoCA scale score of1month and12months. Observe the curative effect of patients undergoing treatment of1month and compare the difference of the three groups on the cumulative life-incidence. It is observed of group B and group C that the different between lamotrigine and sodium valproate in late onset of epilepsy, and it is observed of group A and group B that the different time of taking lamotrigine in late onset of epilepsy. At last, the comparison among three groups help us observing the different of statistical significance of the two kinds of drug.Results(1) Taking follow-up for the108patients, there is1case lost in group A, and0cases lost in group B and2cases lost in group C. In group A, the incidence of EPTS and LPTE are5.71%and2.86%. In group B, the incidence of EPTS and LPTE are8.33%and2.78%. In group C, the incidence of EPTS and LPTE are11.76%and17.14%.(2) Comparing three groups cumulative incidence of LPTE patients, group B below group C (p<0.05), and group A is alike to droup B(P>0.05), and group A, B below group C(p<0.05).(3) Only1patient in group A has rash phenomenon and with the rash symptoms disappeared,the other two groups had no adverse reaction. Liver enzymes and blood of patients are normal, and this shows that head-injured patients who took lamotrigine can have high security.ConclusionThe use of lamotrigine can be security, and it also has better preventive effect and cognitive function of patients with traumatic brain injury, improving the quality of life.