The Analysis Of Copd With The Change Of Coagulation Factor Ⅷ Activity And Antigen

Objective:The patients of chronic obstructive pulmonary disease(COPD) exist ofhypoxia,infection and oxidative stress may lead to vascular endothelial injury.There isclinical and pathological evidence of coagulation-fibrinolysis abnormalities in thepatients of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Because of the vascular endothelial cells are stimulated or injury lead toincrease the synthesis and release of the FactorⅧ. When the Coagulation FactorⅧ isinvolved in the clotting process,the active function is lost,but the antigenicity is stillpreserved.Joint detection of Coagulation FactorⅧ activity and antigen can better reflectthe changes of the coagulation function.This study aim to investigate the correlationanalysis of chronic obstructive pulmonary disease with the levels and significance ofCoagulation FactorⅧ. May early detection of prothrombotic state in patients of theCOPD and provide the basis for the diagnosis and treatment.Methods:40patients with acute exacerbation of chronic obstructive pulmonarydisease(AECOPD) from the First Affiliated Hospital of Dalian Medical UniversityRespiratory January2009to November2010there is complete information as theexperimental group.In addition,40patients with chronic obstructive pulmonarydisease(COPD) from the First Affiliated Hospital of Dalian Medical UniversityRespiratory August2009to August2011there is complete information as the controlgroup.Using the classic biotin double antibody sandwich enzyme-linked immunosorbentassay (ELISA) detected human FactorⅧ-related antigen(FⅧ:Ag).9patients withAECOPD and11patients with COPD the FⅧ:C was detected by the one-stage assay.Results:1.The human FactorⅧ-associated antigen(FⅧ:Ag) results:The AECOPD groupFⅧR:Ag(1191.60±254.26) was significantly higher than the COPD group FⅧR:Ag (733.08±133.00), the difference is of statistically significance(t=-2.688,P=0.009).87.5%patient with AECOPD higher than normal(400ng/L);80%patient with COPD higherthan normal(400ng/L).2.The human factorⅧ activity(FⅧ:C) results:The AECOPD group FⅧ:C(180.46±22.16) was significantly higher than the COPD group FⅧ:C(122.97±20.90),the difference is of statistically significance (t=-5.956,P=0.000).77.5%patient withAECOPD higher than normal(150); the patient with COPD within the normalrange(70-150).3. The FⅧR-Ag and FⅧ:C is a positive correlation (r=0.669,P=0.024) with thechronic obstructive pulmonary disease(COPD).Conclusion:Plasma coagulation factor Ⅷ activity(FⅧ:C) and factorⅧ antigen(FⅧ:Ag) levels may be closely related with the acute exacerbation of chronicobstructive pulmonary disease(AECOPD). Joint detection of Coagulation FactorⅧactivity and antigen may predict disease progression and preventive anticoagulanttherapy of AECOPD.