The Clinical Pathology Of Vaginal Intraepithelial Neoplasia Of51Cases

Objective: The clinical pathology of vaginal intraepithelial neoplasia (VAIN) isused to investigate the clinical characteristics of this disease and improve itsrecognition.Method: Retrospective analysis has been done to51patients with VAINⅠ～Ⅲwho were pathologically diagnosed in Maternity Hospital of Dalian and First AffiliatedHospital of Dalian Medical University from1/2006to12/2011.Results: In51patients,7patients are of VAIN I,12patients are of VAIN II and32patients are of VAIN III.51patients for six years the incidence rate of VAIN were7.84%(4/51),11.76%(6/51),15.69%(8/51),19.61%(10/51),27.45%(14/51),17.65%(9/51), VAIN detection rate has an increasing tendency. VAIN average age ofonset was50.59years old, median age51years, later than the age of onset of CIN andcervical cancer.51patients were divided into three groups:30≤y <40-year-old group,40≤y <50age group,50≤y age group. The three groups VAIN Ⅰ~Ⅲ incidenceof13.7%(7/51),23.5%(12/51),62.8%(32/51), respectively. All ages VAIN theincidence rate of9.8%, respectively,37.3%,59.2%, respectively. Visible the VAINlesion level is increase by increase in age. In51patients, the VAIN merger of CIN IIpatients4cases, the VAIN merger of CIN III patients for6cases, the VAIN merger ofcervical cancer patients of41cases. VAIN III in CIN II, CIN III and cervical cancer rateis1/4,3/6,68.3%, respectively. Thus, VAIN and cervical lesions are important, thelesion level may vary depending on the pathological grade of CIN or cervical cancerincreases. HPV infection is the cause of cervical cancer, CIN, VAIN main risk factor,and HPVDNA detection more sensitive. Genotyping of HPV infections detected inHPVDNA liquid-based thin and histopathology the three of HPV testing positive rates were69.2%,29.4.2%,37.2%, respectively. VAIN of multiple sites for the1/3of thevagina, followed by1/3of the vagina, vaginal middle of the most rare. Line afterhysterectomy patients due to cervical cancer or CIN or other lesions, VAIN good occurin the vaginal stump suture. In VAIN I~III’s patients with lesions of the median, for2,3,3, respectively, the lesions were multifocal distribution.Conclusions: The detection rate of VAIN is a rising trend; VAIN may beincreased with age lesion level also increases; VAIN lesions level may increase with thelevel of CIN and cervical cancer lesions aggravated; HPV infection is a major riskfactor for CIN, cervical cancer, VAIN occurred; VAIN lesions occur in1/3of thevagina, and features the VAIN multiple foci incidence.