Analysis Of Diagnosis And Treatment Of Vaginal Intraepithelial Neoplasia And Correlation To Cervical Intraepithelial Neoplasia

Objective:To investigate the diagnosis and therapy of vaginal intraepithelial neoplasia(VAIN) and correlation to cervical intraepithelial neoplasia(CIN).Methods:The clinical and pathological data about age, liquid-based cytology, human papillomavirus (HPV) DNA test, colposcopy, histological types and treatment in50patients who were visiting in the Department of Gynecology of Nanjing Drum Tower Hospital from2012to2013with VAIN were reviewed to investigate the diagnosis and therapy of VAIN.Results:The patients ranged from31to71years old, mean age at presentation was48.98±10.858years. The percentage of VAINⅠ.VAINⅡ and VAINⅢ were28%(14/50)、38%(19/50)、34%(17/50). The age of high VAIN patients became younger.56%(28/50) or24%(12/50) cases had the history of CIN or cervical cancer respectively.42%(21/50) had a history of hysterectomy,13of them were cervical intraepithelial neoplasia and cervical cancer. VAINⅡ-Ⅲ accounted for3/8,65%(13/20)and83.3%(10/12) of CINⅠ, CINⅡ-Ⅲ and cervical cancer, respectively. There were85.7%(12/14)positive high risk HPV infection in VAINI, while100%in VAINⅡ and VAINⅢ. There were94%(47/50) cased with abnormality for liquid-based cytology and84%(42/50) cases of lesions were located in the upper1/3vagina. The average interval of the VAIN occurrence after hysterectomy with or without cervical disease was3.46years and8.87years respectively. All cases received therapy,3cased recurred.Conclusion:The clinical characteristics of VAIN are similar to CIN.Human papillomavirus infection, cervical intraepithelial neoplasia and cervical cancer, previous hysterectomy due to CIN/cervical cancer were risk factors of VAIN. Cytology(TCT and HPV DNA test)-colposcopic biopies-pathological diagnosis are very important and suitable in diagnosis and follow-up for vaginal intraepithelial neoplasia. Surgical should reserved for the most effective treatment.We agree with that it is essential to have long-term and standard follow-up in cases of the recurrence and survival of Surgical should reserved for the most effective treatment.We agree with that it is essential to have long-term and standard follow-up in cases of the recurrence and survival of vaginal intraepithelial neoplasia.