The Effects Of Alpha-lipoic Acid On Oxidative Stress In Vivo And Urinary Albumin Excretion In Type2Diabetics

Objective To observe the effects of Alpha-lipoic acid on oxidative stress in Vivo and urinary albumin excretion in type2diabetics and explore its possible reno-protective mechanisms.Methods36type2diabetics were recruited as the observation group and treated with ALA on the basis of initial anti-diabetic therapy, and30healthy subjects at the same period were selected as the control group. At the basal and the sixth month after ALA treatment, FBG, HbAlc, oxidative stress parameters(serum activities of super oxide dismutase-SOD,and glutathione, reductase-GSH-Px, serum malonaldehyde-MDA, urinary MDA and8-hydroxy-deoxyguanosine-8-OHdG),urinary albumin(ALB) and urinary creatinine (Cr) were determined, respectively.Results (1) Compared with the control group, serum GSH-Px,SOD activities decreased significantly, serum MDA increased significantly(P<0.01);and urinary albumin/urinary creatinine ratio (UACR), UMCR (UMDA/Ucr),U8CR (U8-OHdG/Ucr) in diabetic patients increased markedly(P<0.01);(2) After six months observation, the levels of serum GSH-Px,SOD activities increased significantly, MDA reduced significantly (P<0.05);and UACR, UMCR, U8CR were significantly reduced in observation group (P<0.01), but there had no significant changes in FBG and HbA1c.(3) UACR had positive correlation with serum MDA, UMCR、U8CR (P<0.01),and negative correlation with serum GSH-Px, SOD activities in diabetic patients(P<0.05).Conclusion ALA can lighten oxidative stress in Vivo in type2diabetics, which may play a protective role for the kidney injury.