The Effects Of Alpha-lipoic Acid On Inflammation Cytokines In Vivo And Urinary Albumin Excretion In Type2Diabetics

Objective To observe the effects of Alpha-lipoic acid on inflammation cytokin in vivoand urinary albumin excretion in type2diabetic patients and investigate its possiblereno-protective mechanisms.Methods36type2diabetic outpatients were treated with ALA (group DA) on the basisof initial anti-diabetic therapy. At the same period,30healthy controls were assigned asthe control group (group NC). The levels of FPG, HbA1c, sICAM-1, urinary MCP-1,TNF-α，UAlb and urinary Cr were determined at the basal and the6thmonth of ALAtreatment, respectively.Results (1) At baseline, the levels of sICAM-1, UACR(UAlb/UCr),UMCR(UMCP-1/UCr)，UTCR(UTNF-α/UCr) in DA group were marked higher thanthose of NC group(P<0.01);(2) After six months observation, the levels of sICAM-1,UACR, UMCR and UTCR were significant decreased in group NC(P<0.01), while nodistinctly changes in FPG and HbA1c.(3) UACR positively correlated with the levels ofsICAM-1, UMCR, UTCR, respectively (P<0.01)Conclusions The present study indicated that ALA could reduce UAlb excretion inpatients with type2diabetics, which may be partly attributed to its effects in decreasingthe excretion of inflammation cytokines and alleviating inflammatory reaction in thelocal kidney.