Analysis The Related Clinicolpathological Influencing Factors For Bone Metastasis Of Breast Cancer After Radical Mastectomy

Objective: To analyze the suspected risk factors that relevant influencing bonemetastasis from breast cancer after radical mastectomy. Provide clinical effectiveprevention and treatment of breast cancer bone metastasis. Methods: A Case-controlretrospective study was made of316breast cancer cases form the Jan.2007to Dec.2007after complex therapy.Patients with Age, primary tumor size, TNM clinical stage,pathological type, axillary lymph node metastasis and the number, HER-2status, HRreceptor status, Ki-67, menopause status, chemotherapy, radiotherapy,endocrine therapy,surgery method, Molecular typing were analyzed the risk factors influencing bonemetastasis. Results: Among316patients, The rate of bone metastasis was19.0%(60/316).The most conllilon sites of bone metastases were the spinal column(50.0%),thechest(32.1%), the pelvis(12.5%), the body(3.58%)and so on;With univariate analysis,primary tumor size,TNM clinical stage,axillary lymph node metastasis and the number,HR receptor status, Ki-67, radiotherapy,endocrine therapy, Molecular typing associatedwith bone metastasis after radical mastectomy.With multivariate analysis by COXRegression showed that axillary lymph node metastasis and the number, primary tumorsize, HR receptor status, Ki-67, endocrine therapy were independent factors associatedwith bone metastasis after radical mastectomy.endocrine therapy was protectivefactor.Conclusions: The study indicates that Positive axillary lymph nodes, the primarylesion is too large, HR receptor-negative, Ki-67-positive is a major risk factor for breastcancer after bone metastases. After endocrine therapy can effectively reduce bonemetastasis incidence. This provides the basis for the prevention of breast cancer after bonemetastases.