Analysis Of Clinico-Pathologic Factors Relating Between Breast Cancer And Bone Metastasis

Objective:To investigate the suspicious clinico-pathologic factors that correlate the occurrence of bone metastasis from breast cancer, to provide early diagnosis and treatment.Methods:A retrospective analysis of 200 breast cancer patients who were hospitalized in The First Affiliated Hospital of Guangxi Medical University between January 2007 and April 2015. The study discuss the relationship between age, menopausal status, primary tumor size, surgical method, histological type, and number of axillary lymph node involvement, hormone receptor status, HER-2 receptor status, sub-clinical types, Ki-67, P16, p53, serum CEA, CA125, CA153, chemotherapy, radiotherapy, endocrine therapy with breast cancer and bone metastasis.Results:Among 200 cases of breast cancer patients,84 patients were diagnosed with bone metastasis. After univariate analysis, primary tumor size, axillary lymph node involvement, HER-2, sub-clinical types, Ki-67, P16, tumor markers, chemotherapy, hormonal therapy have a significant association between breast cancer and bone metastasis (P<0.05). According to multivariate logistic regression analysis, primary tumor size, serum CA125, CA153, axillary lymph node involvement play the major risk factors that impact the occurrence of bone metastasis from the breast cancer. Chemotherapy and endocrine therapy are found to be the protective factors for bone metastasis.Conclusion:The breast cancer patients whose primary tumor size more than 5cm with the axillary lymph node involvement and the high serum CA125,CA153 level tend to have bone metastasis than the other breast cancer patients. But, postoperative chemotherapy and endocrine therapy can effectively reduce the incidence of bone metastasis. This provides some basis for early detection and treatment of breast cancer patients with bone metastasis.