Non-invasive Measurement Of Blood Glucose Based On Photoacoustic Principle And Its Experimental Study

Diabetes is a disease which could jeopardize our human health. Thedetermination of the blood glucose level is the key procedure in diabetes precautionand therapy. The method of photoacoustic not only provides an economic way toavoid the shortcomings of biochemical test methods,just like reducing materialwastage and speeding up measurement,but also is a potential method of non-invasiveblood glucose measurement.Great deal of research work about non-invasive glucosemonitor method has been carried out.Despite considerable progress, however, untilnow truly non-invasive glucose monitor in blood is not a reality.This research is carried out according to the test of blood glucose based onprinciple of photoacoustic.Firstly, according to the absorption of glucose in thenear-infrared region,we design a system on account of photoacoustic principle,whichconsists of laser, optical, ultrasonic probe, amplifier and oscilloscope.Secondly, bymeasuring the absorption peak of glucose, determine the wavelength of1510nm,1890nm,2020nm as the measuring wavelength.Then configure100-500mg/dlglucose solution, and utilize the above mentioned wavelength to measure the glucoseconcentration of the solution. The amplitude of the acoustic signal and the glucoseconcentration of the solution is a non-linear relationship. Finally, on the basis of themethod of least squares analysis, we fit the measurement results, and obtain themeasured mean square error for6.202mg/dl. It has not reached the measurement ofnear infrared spectroscopy (5.4mg/dl).Based on the above results, analysis of the experimental system, improvingexperimental light path, promoting the ultrasonic probe frequency, and using lock-inamplifier to remove the noise interference,which could improve the signal-to-noiseratio to provide a basis for better experimental data,will be done step by step. Finallythe experimental data is analyzed and the mean square error of glucose solution is3.93mg/dl. This result is better than the near-infrared measurement and furtherconfirm the feasibility of the photoacoustic measurement of blood glucose.