Expression And Significance Of YY1mRNA In Peripheral Blood Of Patients With Esophageal Squamous Cell Carcinoma In Xinjiang Kazak

Object: This study is to investigate and compare the expression of transcription factor YY1in peripheralblood of patients with esophageal squamous cell carcinoma in Xinjiang Kazak. To explore its relationshipand to find valuable micrometastases markers with esophageal squamous cell carcinoma in Xinjiang Kazak.It hopes to provide a beneficial exploration and theoretical basis at high-risk groups of census and earlydiagnosis of esophageal micro transfer, judge malignant degree, guiding clinical treatment of esophagealcancer through the peripheral blood.Moethds:The expression of YY1genes were detected in40peripheral blood cases of esophageal cancer andnon-esophageal cancer by reverse transcription polymerase chain reaction (RT-PCR).Results:The expression of YY1mRNA was found positive in1cases among40peripheral blood cases ofnon-esophageal cancer (positive rate2.5%).The YY1mRNA positive rate of40patients with esophagealsquamous cell carcinoma was47.5%(19/40).With the increasing degree of malignancy and diseaseprogression, the positive rate rised gradually(P<0.05), YY1mRNA in well-differentiated squamous cellcarcinoma positive rate(21.05%) was significantly lower than that of poorly differentiated squamous cellcarcinoma (81.82%)(P<0.05).Conclusion:1.YY1mRNA has the high expression in peripheral blood of patients with esophageal squamous cellcarcinoma. It may play an important role in the development of esophageal cancer.2.The positive expression rate of YY1mRNA was significantly higher than the control group inperipheral blood of patients with esophageal squamous cell carcinoma in Xinjiang Kazak. YY1is a goodmarker for screening of esophageal cancer.