A Polymorphism In ACE2Gene And Diabetes Promoter Increases Risk For Coronary Heart Disease

Objective:1. To evaluate the polymorphism of G8790A gene of angiotensin converting enzyme2and its relationship with coronary heart disease in type2diabetetic patients andunderstand the susceptible genes in type2diabetic patients with coronary heartdisease.2. To search for the genotype of the effects on the Cardiac Functions and it’s helpfulto guide clinical treatment.3. To search for the genetic factors of the type2diabetic patients with coronary heartdisease, and then analyze its etiology and mechanisms from the genetic point ofview.Methods:There were three groups as follow: the control group including50cases of healthyindividuals, the simplex CHD group of42cases and the type2diabetes group of108cases. Among the third group, portion were the simplex type2diabetes of43casesand other were diabetic patients with coronary heart disease of65cases. All theselected candidates had been exsanguinated to examine blood biochemistry, brainnatriuretic peptide and specimensed from blood specimen to detect the genepolymorphisms.Results:1. Between any two groups was showed that only the frequency difference of G alleleof male T2DM+CHD group was statistically significant (X2=10.981, P=0.006),while the allele and frequency distribution were not statistically significant among anygroup of the women(genotype: X2=0.764, P=0.926, gene frequency: X2=0.035, P =0.975).2. Logistic regression analysis showed that the susceptible gene of T2DM with CHDwas the G allele among the men (P=0.035, OR=2.231,95%Cl=1.075-5.135),while the G allele and T2DM with CHD was in no correlation among the women(P=0.035, OR=1.457,95%CI=1.033-2.576).3. Only in the male T2DM+CHD group, the NT-proBNP values of G allele werehigher than the A genotype and their differences were statistically significant（X2/Z=-2.675,P=0.004), while there was no statistically significant between maleand female in the other three groups.Conclusions:1. The incidence of G8790A polymorphisms with T2DM and CHD (do not mergeT2DM) is no significant correlation.However, it is related to T2DM with CHD formales and its susceptible gene is possible the G allele in the pathogenesis.2. When male patients suffer from T2DM and CHD at the same time, the incidence oftheir heart dysfunction is some correlated with the G allele.