The Research Of Radiation Treatment Of Bone Hydatid Disease

Objective:Explore the efficacy that radiation (6WV-X-ray) treat bone hydatiddisease.Method:Establish seventy gerbils bone hydatid disease animal models which wererandomly divided into four groups, one group was to be control group, the animal modelsin other three groups were given40GY/5times,50Gy/5times,60Gy/5times,6MV-Xray positioning radiotherapy,3months later(the end of radiotherapy),toobserve the gerbils,general situation,to compare the mortality of scolex、protein andcalcium concentration in capsule fluid,to observe the pathological changes of the hornylayers and germinal layers，the varying of the bone cells in the irradiation areas and theultrastructure of echinococcus granulosus cysts.Result:Over the past3months,gerbils ineach group has death cases, but the survival ones,general behaviors were normal. Amongthe groups, the difference of the mortality of scolex（such as Control group:22.6,40Gy/5time group:96.6,50Gy/5time group:131.5,60Gy/5time group:155.5）wasstatistically significant (P <0.01). Protein concentration（calcium ion concentration） incyst fluid decrease（increase） with irradiation doses increase, The protein (calcium)concentrations are such as-the control group:1.0241(2.8875),40Gy/5time group:0.7245(3.0541),50Gy/5time group:0.6171(3.5446) Gy to60Gy/5time group:0.5058(3.8241),which comgpared among each group there were significant differences(P<0.01).Histopathological results showed that echinococcus sac in the treatment groupsshowed different degrees of degeneration or necrosis, which compared with control groupthere were significant changing. Compared between40Gy and50Gy group,40Gy and60Gy group, the pathological changes of echinococcus sac were significant difference (P<0.01),but between50Gy and60Gy group the pathological changes is not obvious (P= 0.359). The bone cells of the irradiated groups have been varying degrees of degenerationor necrosis. By electron microscopy, with the irradiation doses increase, the horny layersand germinal layers have been varying degrees of damage. Conclusion:Radiation therapyis effective for bone hydatid disease, but need to select the appropriate radiation doseaccording to the actual situation, to prevent the occurrence of irreversible osteonecrosis...