A Study Of Infection Rate Of Human Papilloma Virus In Different Period Of Pregnancy And Vertical Transmission On Fetus

Objective: Carrying out HPV detecting on the secrete of woman cervix betweendifferent period of pregnancy and non-pregnancy in order to discuss its infection rate.And investigate the vertical transmission on fetus. Methods: High risk HPV-DNAdetections were done by HC-Ⅱ,in order to check20specimens which examined inXinjiang General Hospital from January2011to December in different period ofpregnancy and healthy women of non-pregnancy respectively, and carrying out HPVinfection rate.24HPV positive pregnant women(study group)and36HPV negativepregnant women(control group)were recruited in this study in order to analysis outcome ofpregnancy. Pharynx and vulvas secretion of the newborn in study group was tested forHPV infection. Results:1.In20specimens of non-pregnancy, the infection rate was15%.In20different gestational women, early, middle, late pregnant period infection rates were20%,35%and65%respectively;2. In20specimens of pregnancy,55.56%in the group≤30years old and27.27%in the group<30years old; The infection rate of each in4groupswas70%,47.06%,20%and50%, respectively;3. For the study group, no pregnancy wasterminated during the first and second trimester,11women had spontaneous vaginaldelivery (45.8％)，13women had cesarean section(54.2％)．The percentages of prematurerupture of membrane, puerperal hemorrhage, fetal distress, premature delivery andpuerperal infection in vaginal delivery group were no difference compared with those incesarean group(P>0.05);4.24babies were born in the study group,11babies(45.83％) hadHPV positive result,5babies were vaginal delivary,6babies were cesarean section, therewas significant difference between the two delivery modes. Conclusion: The infectionrate in our study is as same as that in non-pregnant women. It is obviously that theinfection rate is higher in pregnant women than non-pregnant women. With theadvancement of pregnancy, the infection rate of HPV become higher and higher.There issignificant difference in different age groups. HPV can be vertically transmitted. cesarean section can not prevent newborns infection. HR-HPV-DNA screening is necessary andsafe in diagnosis of cervical diseases.