Synthesis And Biological Activity Of Oximide-bridged Dicopper(Ⅱ) And Carboxymethyl Chitosan-rare Earth(Ⅲ) Complexes

Following the discovery of the anti-cancer activity of cisplatin successfully used inclinical design and development of new anti-cancer activity of metal complexes drugs, hasbeen inorganic medicinal chemistry research focus. Based on a number of anti-cancer drugsbased on DNA as a target, the paper metal complexes with DNA interaction studies as astarting point to look for efficient, low toxicity and antitumor activity of metal complexesas the main research goals, asymmetric synthesis oxamide ligands and synthesis as a basisfor its copper complex, the complex crystal, molar conductance, IR and electronic spectraof the complexes were characterized by single crystal X-ray diffraction; and the role ofthese complexes with herring sperm DNA, and its mechanism of action. In addition, thestudy for marine polysaccharide-chitosan and its derivatives and REE complexes dosynthetic carboxymethyl chitosan and synthetic ligands three carboxymethyl shell glycans-rare earth complexes. Their structures were characterized using IR, UV spectrum. In orderto understand the toxicological characteristics, select the carboxymethyl chitosanLanthanum （Ⅲ） complexes as experimental subjects, experimental animal experiments andbroiler experiment of its toxicity analysis.This thesis consists of two sections as follows:1. A new dissymmetrical N,N’-bis（substituent）oxamide was synthesized and characterized.By controlling counter anions, pH values and solvents, bicopper（Ⅱ） complexes,[Cu₂（pdmaeox）（DABT）（CH₃OH）Cl]（CH₃OH）, was obtained and characterized byelemental analyses, IR and electronic spectra and single-crystal X-ray diffraction.2. By using carboxymethyl chitosan as ligands, three carboxymethyl chitosan-rare earth（Ⅲ）complexes （CSLC） were synthesized and characterized by IR, UV spectra. Selectcarboxymethyl chitosan-based lanthanum（Ⅲ） complexes as experimental subjects, theirtoxicology, mouse oral acute toxicity test, rats30d feeding trials and broiler experimentproved CSLC nontoxic substances, which can be used as feed additives for broilerfeeding.