Expression Of PTEN、VEGF And Ki-67in Glioma And Their Clinical Significances

Objective: To investigate expressions of phosphatase and tensin homologdeleted on chromosome ten (PTEN), vascular endothelial growth factor （VEGF）and Ki-67in glioma tissues,and their correlations with gliomamalignancy.Methods: The expression of PTEN、VEGF and Ki-67in60cases ofglioma and10cases of normal brain tissues were detected byimmunohistochemistry, and their correlations with glioma were statisticallyanalyzed.Results: There was a significant difference in the positive rates ofPTEN、VEGF and Ki-67between normal brain tissues and glioma (P＜0.05).There was a significant difference between low grade glioma and high gradeglioma (P＜0.05). In normal brain tissue, the expression of PTEN was highter. Thepositive reaction rate of PTEN was decreased with the increase of tumormalignancy．The expression of VEGF and Ki-67in normal brain tissues were littledetected. The positive reaction rate of VEGF and Ki-67was increased with theincrease of tumor malignancy. Conclusions: The decrease of the expression ofPTEN may have very important effect on development and growth of glioma. Theexpression of VEGF and Ki-67mirrors the general rule of cell multiplication anddifferentiation of glioma. Combined detection can estimat the biological behaviourand prognosis of the patients more exactly.