The Absolute Lymphocyte Count、the Absolute Monocyte Count And ALC/AMC Ratio Are Associated With Prognosis In Non-Hodgkin’s Lymphoma

Objective:To analyze the prognostic factors of non-Hodgkin’s lymphoma(NHL) and to investigate the prognosis value of peripheral blood absolute lymphocyte count(ALC) peripheral blood absolute monocyte count(AMC)、the ratio of the absolute lymphocyte count to the absolute monocyte count (ALC/AMC ratio).Methods:We retrospective analyzed data from229patients diagnosisd as non-Hodgkin’s lymphoma by pathology from January2007to September2012, to study the correlation between clinical parameters、pathological features、treatments [such as sex、age、 Ann Arbor stage、the number of extranodal sites of disease、Eastern Cooperative Oncology Group performance status、B symptoms、pathological pattern、origin of cell、lactate dehydrogenase(LDH)、the international prognostic index(IPI)、the revised International Prognostic Index (R-IPI)、bone marrow involvement、bone destruction、mediastinum involvement、hepatosplenomegaly、serous cavity effusion、bulky、the peripheral blood absolute hemoglobin count(HB)、the peripheral blood absolute lymphocyte count、the peripheral blood absolute monocyte count、ALC/AMC ratio、autotransplantation、allotransplantation] and5years overall survival (OS)、5year event-free survival(EFS).Results:The median patient age was46(4.8-83) years, the median follow-up time was300(6-2610) days. In univariate analysis age>60years, origin of cell was B cell lymphoma, pathological pattern was follicular lymphoma, without B symptom, the number of extranodal sites of disease<2, Eastern Cooperative Oncology Group performance status<2, normal LDH, Ann Arbor stage Ⅰ-Ⅱ, low IPI score or low R-IPI score, without bone marrow involvement, without hepatosplenomegaly, without serous cavity effusion, without mediastinum involvement, HB>=110g/l, ALC=1000/ul, AMC...