A Clinical Trial Of Mupirocin Ointment In Prevention Of Trauma Orthopedic Postoperative Wound Infection

Objective：Orthopedic postoperative wound infection is one of themost serious complications in orthopedic surgery, prevention of orthopedicpostoperative wound infection is very important. In this clinical trial,mupirocin ointment is used to patients with orthopedic surgery in order toevaluate whether mupirocin ointment effectively reduce the morbidity oftrauma orthopedic postoperative wound infection.Methods：According to the inclusion criteria,415cases of patientsin internal fixation surgery are chosen from our hospital, from February2012to September2012.415cases are randomly divided into theexperimental group (196cases) and control group (219cases). Wounds aredressed with mupirocin ointment in experimental group, and withiodophor in control group. Record patients’ age, surgery method, surgicalsite, surgical time, blood loss and infection cases. Use SPSS statisticalpackage to analyze these data.Results: There are no statistical differences in the age, sex, woundlocation, surgical time, and blood loss between the two group（sP>0.05）.In the experimental group, one patient has poor wound healing (morbidity0.51%), infection does not appear.13patients in the control group havepoor wound healing (morbidity5.94%), wound infection in5cases(morbidity2.28%). Postoperative wound infection morbidity in theexperimental group is significantly lower than in the control group (P<0.05).Conclusion：Using mupirocin ointment can effectively reduce themorbidity of trauma orthopedic postoperative wound infection.