The Correlation Between The Grade Of Plasma D-dimer And Fibrinogen And The Malignancy Degree Of Glioma

Objective:To investigate the correlation between the grade of plasma D-dimer and fibrinogen with the malignancy degree of glioma and prognostic of glioma patients, and to provide an important evidence for evaluating the malignancy degree of glioma and prognosis of the glioma patients.Methods:59plasmas of glioma patients were investigated for the grade of plasma D-dimer and fibrinogen from January2009to February2011in the Affiliated Fourth People’s Hospital of Zigong City of Luzhou Medical College. The Experimental group included26patients of glioblastoma (WHO IV),15patients of anaplastic astrocytoma (WHO Ⅲ),16patients of astrocytoma (WHO Ⅱ),2patients of capillary astrocytoma (WHO Ⅰ),13patients of meningioma (WHO Ⅰ). Additionally, we chose20healthy people as the control group. We devided the objects into four groups, the malignant glioma group(WHO Ⅲ-Ⅳ),the low malignant glioma(WHO Ⅰ-Ⅱ), the meningioma group, and the healthy group. We collectd the venous blood of the4groups, and measured the grade of plasma D-dimer and fibrinogen by the meathod of colloid gold before the operation of the patients. And then the patients were fellow-up till24months later, unless someone died. To investigate the correlation between the level of plasma D-dimer and fibrinogen and the malignancy degree, the recurrence and the prognosis of the glioma patients.Result:The level of plasma D-dimer and fibrinogen increased in30cases, unchanged in11cases in the malignant glioma group,; none increased in the low malignant glioma group, the meningioma group and the healthy group. The difference of the level of plasma D-dimer and fibrinogen between malignant glioma group, the low malignant glioma group, the meningioma group and the healthy group was statistically significant (D-dimer t’=8.3972, P<0.05; fibrinogen t’=10.1236,P<0.05). The difference of the level of plasma D-dimer and fibrinogen between low grade glioma group, meningioma brain tumor group, and healthy group was no statistically significant (P>0.05). None died or occurred venous thrombosis in24months follow-up in the low grade glioma group, benign brain tumor group and healthy group.29people died and10people occurred venous thrombosis in the30cases whose level of plasma D-dimer and fibrinogen increased in the malignant glioma group.2people died and no people occurred venous thrombosis in the11cases whose level of plasma D-dimer and fibrinogen were normal in the malignant glioma group. The level of plasma D-dimer and fibrinogen was associated with the prognosis of the malignant glioma patients.Conclusion:The level of plasma D-dimer and fibrinogen maybe associated with the malignancy degree of gliomas. The increased level of plasma D-dimer and fibrinogen maybe associated with poor prognosis and high mortality of malignant gliomas.