Study On Correlation Between Carotid Artery Intima-media Thickness And Adiponectin In Patients Of Type2Diabetes Mellitus With Non-alcoholic Fatty Liver Disease

Objective：To study the correlation between carotid artery intima-mediathickness and adiponectin in Patients of type2diabetes mellitus withnon-alcoholic fatty liver disease. Methods：85cases with T2DM were dividedinto two groups: with non-alcoholic fatty liver disease (DM+NAFLD, n=41)and no non-alcoholic fatty liver disease (DM, n=44). The serum levels of fastingplasma glucose(FPG), fasting insulin(FINS), Adiponectin， low densitylipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol (HDL-C),total cholesterol(TC), triglyceride (TG) and intima-media thickness (IMT) weredetected. homeostasis model assessment of insulin resistance (HOMA-IR) andBody mass index (BMI) were calculated. Results:①T he levels ofBMI、FPG、TG、TC、LDL-c were higher in DM+NAFLD group compared to the controlcases (P<0.05).②The levels ofFINS and HOMA-IR were higher inDM+NAFLD group compared to control group (P<0.05OR P<0.01).③Thelevels of IMT-L、IMT-R were higher in DM+NAFLD group compared to thecontrol case（sP<0.01）, and the levels of Adiponectin was lower than the controlcases(P<0.05).④IMT was positively correlated with BMI, FPG, TG，LDL-CHOMA-IR and FINS (P<0.01), but negatively correlated with APN, HDL-C （P<0.05）. Conclusions: Type2diabetes individuals with non-alcoholic fattyliver disease have more obvious features in insulin resistance, glucolipidemetabolic disorder and low adiponectin level than no non-alcoholic fatty liver intype2diabetes mellitus, and it is related to the development of atherosclerosis.