Clinical Study Of Acarbose In The Treatment Of Patients With Type 2 Diabetes Mellitus Complicated With Nonalcoholic Fatty Liver Disease

Objective: Explore the interventional effect of acarbose in the treatment of patients with both type 2 diabetes mellitus(T2DM)and non-alcoholic fatty liver disease(NAFLD)by studying the relationship between the adiponectin(APN),C-reactive protein(CRP)and intima-media thickness(IMT).Methods: The research subjects were 73 patients with both T2 DM and NAFLD,and divided into two groups by by random number table method.Diet and exercise intervention were adopted together with oral pravastatin(10mg qn),dimethyldiguanide(500 mg tid)and repaglinide(0.5-1.0 mg tid).Patients in the control group were given acarbose tablets for 24 weeks at a dose of 50 mg tid.Measure the indicators before and after the treatment such as the fasting plasma glucose(FPG),2-hour postprandial blood glucose(2hPG),hemoglobin A1c(HbA1c),fasting insulin(FINS),blood lipid,alanine aminotransferase(ALT),aspartate aminotransferase(AST),APN and CRP.The correlation of IMT-L,IMT-R with APN and CRP was studied.Results:1.After the acarbose treatment,the APN of the control group was increased(P<0.05);CRP and FINS were significantly decreased(P<0.05);IMT-L was also declined(1.28±0.12vs1.19±0.12,P<0.05);IMT-R was declined but had no statistical differences(1.23±0.09vs1.20±0.08,P>0.05).2.The indicators such as APN,CRP,IMT-L and IMT-R of the observation group patients before and after the treatment had no statistical differences(P>0.05).3.IMT-L and IMT-R of two groups before the treatment had negative correlation with APN(P<0.01),but had positive correlation with CRP and HOMR-IR(P<0.01).4.After the oral acarbose treatment,the changes of IMT-L and IMT-R for the control group had negative correlation with the change of APN(P<0.01),but had positive correlation with the changes of CRP and HOMR-IR.Conclusion:1.Acarbose could reduce the inflammation response,ameliorate insulin resistance,improve blood sugar metabolism and balance of patients with both T2 DM and NAFLD by influencing the CRP,APN and HOMR-IR.2.Acarbose might effect the CRP,APN and HOMR-IR of patients with both T2 DM and NAFLD,hence slow the development of IMT and then retard the atherosclerosis.