Clinical Observation Of Adult Henoch-Sch(o|")nlein Purpura Nephritis Patients’ Treated With Yiqi Yangyin Huoxue Decoction

Objective:To study the clinical treatment for the adults who are in the deficiency of both Qi and Yin with blood stasis syndrome of Henoch-Schonlein purpura nephritis (HSPN) with Shenqi Dihuang Decoction and Siwu Decoction combined with Prednisone Acetate, to explore the effect and safety of Yiqi Yangyin Huoxue Decoction of adult HSPN.Method:43patients met the inclusion criteria of deficiency of both qi and Yin with blood stasis syndrome of HSPN, were randomly divided into control group (21cases treated with Prednisone Acetate) and treatment group (22cases treated with Shenqi Dihuang Decoction Siwu Decoction combined with Prednisone Acetate). The length of treatment is2months. Before and after treatment,to evaluate the therapeutic effect by observing two groups’main symptoms, and the quantity changes of the urine red blood cell, and24hour urinary protein;and to evaluate the drug safety by observing the changes of blood routine、renal function and liver function of two groups of patients.Results:(1)In treatment group, the total effective rate of therapeutic effect were90.91%, higher than71.43%in control group, P<0.05.(2)The treatment group and the control group with efficiency rate of TCM syndromes were90.91%and57.14%, P<0.05; TCM symptom integral results:before and after treatment, within group comparison were P<0.05, the comparison of after treatment between two groups was P<0.05. The treatment group in improving the clinical manifestations of patients is better than the control group.(3) All the two treatments decreased red blood cells in urine (P<0.05), but the efficacy of treatment group was more significant (P<0.05).(4)Two kinds of treatment can effectively reduce the urinary protein (P<0.05), but the treatment group was better than the control group (P<0.05).(5)Before and after treatment, the within group comparisons of main symptom scores: the main symptoms of patients in the treatment group were improved after treatment (P<0.05), the control group patients except feverishness in palms and soles and soreness and weakness of waist and knees symptoms without improvement(P>0.05),the other symptoms were improved (P<0.05).After treatment,the comparison among groups:the curative effect of treatment group is superior than the control group in improving the main TCM symptoms (P<0.05).(6)After treatment, the Scr、BUN、AST、ALT and WBC of two groups had no significant change(P>0.05),there were no abvious damege of renal and liver functions anddecrease of WBC.Conclusion:Yiqi Yangyin Huoxue Decoction combined with Prednisone Acetate, in the treatment of the adult patients in the deficiency of both qi and yin with blood stasis syndrome of HSPN, can improve the clinical symptoms and physical signs of patients, reduce proteinuria and hematuria, enhance the treatment effect and decrease the side effect of hormone, also can exactly improve the quality of patients’life with high curative effect.It is worth for further study and promotion.