Value Of Diffuse Tensor Imaging And Susceptibility Weighted Imaging In Diagnosis Of Traumatic Brain Injury-animal Experiment Study And Clinical Observation

Objective:By comparing the analysis results of DTI and traumatic brain tissue pathologicalslices,the animal model of DAI was established to discuss early MRI Functionalimaging findingsMothods:Through the use of biological impact machine hit the big white rabbit head, mildand severe DAI injury model was established.Twenty rabbits were subjected to braintrauma group (mild14and severe6)and5rabbits were enrolled as control group.brain trauma group undretook routine MRI、 SWI and DTI at3hours afterinjury,mild group undretook routine MRI and DTI at the time points of one day, oneweek after traumatic event,and then contrasted with histology.Result: Compared with the control group, severe group have5cases with skullfracture,5cases of subarachnoid hemorrhage,2cases of cerebral contusion.Asignificant increase in FA indices in severe group versus control group wasobserved(P<0.01).Apparent diffusion coefficient(ADC) and the radial diffusiondecreased(P<0.05),no significant axial diffudion(AD) change was detected. HEstaining showed neurons swelling, cytoplasm, dye, limited inflammatory cellsinfiltration, not obvious ARBs. Compared with the control group, mild group aren’t3cases of skull fracture, one case of subarachnoid hemorrhage, and no obviousintracranial hematoma formation.Mild group3hours after traumatic,all diffusionparameters without any change. Mild group one day after traumatic,FA obviouslyincreases(P<0.01)and RD decreases,AD and ADC has no obvious change. Mild groupone week after trauma, no significant all parameters change was detected. Severegroup "abnormal vascular sign" is higher than mild I group and the control group.Conclusion: By using the linear acceleration device hit rabbit, We made DAI animal model.The FA value of the corpus callosum increase in acute stage of DAI,ADC valuedecrease,it is given priority to with cytotoxic edema."abnormal vascular sign"suggests the brain blood oxygen metabolic abnormalities.DTI and SWI is a kind ofsensitive imaging method for exploring DAI occurrence and development process,which can provide referential images for early DAI diagnosis. By using DTI and SWItechnique examine TBI patients, we can provide the image reference for earlydiagnosis and treatment of DAI. Objective:analyze relationship between white matter parameters and cognitive function byusing diffusion tensor imaging.Mothods:select17traumatic brain injury patients and17controls.Each participate arechecked by by using diffusion tensor imaging and MMSE，then measure FA andADC value of genu corpus callosum、splenium corpus callosum、anterior internalcapsule、 posterior internal capsule and cerebral peduncle.We discuss whethercorrelation between FA and ADC value of white matter and MMSE.Result:compared with control group，A significant decrease in FA indices of genucorpus callosum and splenium corpus callosum in middle-severe group was observed，ADC value of genu corpus callosum、splenium corpus callosum、posterior internalcapsule and cerebral peduncle increase. A significant change in FA and ADC indicesin mild group versus control group was not observed.There is correlation between FAand ADC value of genu corpus callosum and splenium corpus callosum and MMSE.Conclusion:DTI is a kind of sensitive imaging method for finding white matter lesion. whitematter FA and ADC values and MMSE score linearly related. FA and ADC values ishelpful to evaluate the cognitive function in patients with TBI.DTI help to providethe diagnostic basis of cognitive impairment in patients with TBI.