Clinical Studies And Mechanism Of Regulating Liver And Stomach Side Treatment Of Bile Reflux Gastritis(Disharmony Of Liver And Certificate)

Objective: To observe tune liver and stomach Treatment of bile reflux gastritis (BRG)(liver and stomach syndrome) clinical efficacy and safety of simultaneous determination ofpatients with bile acid (TBA), epidermal growth factor (EGF), prostaglandin E2(PGE2),tumor necrosis factor-alpha (TNF-alpha), interleukin-8(IL-8) content, to explore itsmechanism.Methods: selected60cases, patients were randomly divided into test group(30cases) and control group (30cases), respectively, subject to adjustment decoction ofthe liver and stomach side and aluminum magnesium carbonate (up to hi) oral. Duringtreatment stop taking other drugs, four weeks for a course, the governance a course, unifiedreview. Were compared before and after treatment TBA, EGF, PGE2, TNF-α, IL-8contentand After treatment, the total efficiency of traditional Chinese medicine symptom efficacy,safety comparison.Results: After treatment, the total effective rate: total effective rate was96.67%in the experimental group, the control group, the total effective rate was83.33%,the efficacy of the test group than the control group, the difference was statisticallysignificant (P <0.01); two group TCM symptoms, total symptom score after treatment thanbefore treatment have improved to some extent (P <0.01), but the treatment in theexperimental group to improve the patient’s bloating, stomach pain, mouth pain, not Yushi,depression or irritabilitymore effective than the control group (P <0.01或P <0.05), while ina noisy, acid regurgitation, the two groups to improve the situation, there was no difference(P>0.05); endoscopic treatment: Test total effective rate was93.33%in the control grouptotalefficiency of76.67%, the test group than the control group was statistically significant(P <0.05); both groups were reduced to varying degrees TBA and gastric mucosal inflammatory factors TNF-alpha, IL-8content, increased EGF, PGE2content (P <0.01或P<0.05), but the experimental group than the control group, the difference was statisticallysignificant (P <0.01或P <0.05).Conclusion: tone the liver and stomach side is safe andeffective prescription treatment BRG, its mechanism of action by reducing TBA, gastricmucosal inflammatory factors TNF-alpha, IL-8content, reduce the reflux liquid on gastricinflammatory damage orhigh EGF, PGE2content, increase mucosal blood flow, to repairthe gastric mucosa, to enhance gastric mucosa barrier function, in order to achieve thepurpose of treatment of this disease.