| Objective: To explore the peroxidase scion activated receptor-β（PPAR β） in thedevelopment of acute lung injury (ALI) in lung tissue apoptosis may, in order to from anew perspective to reveal the pathogenesis of ALI/ARDS, and offers a new theoreticalbasis for prevention and control of ALI/ARDS.Methods: Reference Cainazzo et al. The duplicate ALI in rats model ofuncontrolled hemorrhagic shock, according to the principle of completely randompoints12SD rats into two groups, uncontrolled hemorrhagic shock induced acute lunginjury model group (group A) and GW0742group (group B),6rats in each group.2hours after building in arterial blood, determination of arterial blood oxygen partialpressure (PaO2). Bleeding after the sudden death, take a piece of the left lungformaldehyde fixed after preparation section, pathologic morphology examination;More than left lung wet weight according to jump bronchoalveolar lavage, collectingbronchoalveolar lavage fluid (BALF) and single cell suspension, right lung withAnnexin V/PI double dye method detection of cell apoptosis rate; Left lung after lavagein the oven to80℃within24h after the dry weight, dry roasted and calculate the lungwet/dry weight (W/D) values.Results: The PaO2of B group were significantly increased in group A (P <0.05).Group B, pathology integral, W/D ratio in the BALF cells and lung tissue apoptosis ratethan in group A was significantly decreased (P <0.05).Conclusions: GW0742PPAR β agonist, inhibit apoptosis of ALI some degree of protective lung tissue, reduce ALI inflammation of lung tissue, improve PaO2. PPAR βplays an important role in ALI occurrence and development. |
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