The Correlation Of Serum IGF-1, IGFBP-3and Ins With Multiple System Atrophy

Objective: Insulin-like growthfactor-1， Insulin-like growth factor bindingprotein-3and insulin are three of the most important factors in the Insulin-Like GrowthFactor System. They play an important role in the growth, differentiation, repair andregeneration of the nervous system process. They can protect the neuronal cells andpromote the regeneration of neuronal survival as well as renew the movementneurons.Multiple system atrophy is a neurodegenerative disease, which etiology isunknown and has complex pathogenesis. It is characterized by various combinations ofParkinson, cerebellar, autonomic, and pyramidal signs. The aim of this study was toknow the correlation of Serum IGF-1, IGFBP-3and Insulin with multiple systematrophy.Methods: There are30patients with multiple system atrophy (18MSA-P,12MSA-C) and20healthy subjects. The patients with multiple system atrophy werecollected from the First Affiliated Hospital of Dalian Medical University medical.Thediagnose of MSA was made according to the criteria which was made by Gilmanin2008. Clinical status of each patient was evaluated with the Unified Multiple SystemAtrophy Rating Scale (UMSARS) Part II (Motor Examination Scale).The levels ofserum IGF-1,IGFBP-3and insulin were determined by Chemiluminescenceimmunoassay in the Nuclear Medicine Laboratory of the First Affiliated Hospital ofDalian Medical University medical under the same conditions. The dates were usedSPSS11.5statistical packages by statistical analysis and mean a significant level of0.05.Results: Serum IGF-I levels were significantly higher in MSA [161.44（59.93）μg/l]than in healthy controls [110.3（36.7）μg/l p=0.003]. Serum IGFBP-3levels weresignificantly higher in MSA[4064.33（826.68）μg/l] than in healthy controls[3543.00（703.14）μg/l p=0.025] too. Serum IGF-I and IGFBP-3levels were significantly and inversely correlated with the age of onset and were higher in the women than in theman，but there were no correlation with UMSARS-Ⅱ scores, the subtype of MSA（MSA-P,MSA-C）and the course of disease. There was no difference in Ins valuesbetween MSA and healthy controls (p=0.178).The levels of Ins were not correlated withthe age of onset, sex, UMSARS-Ⅱ scores,the subtypes of MSA（MSA-P,MSA-C）andthe course of disease.Conclusion：1. There were two subtypes of multiple system atrophy, such asMSA-P and MSA-C, respectively accounted for60%and40%.The mean onset age ofMSA was57and there were no gender differences in the incidence of multiple systematrophy.2. The levels of serum IGF-1and IGFBP-3were significantly higher inmultiple system atrophy and were negative correlation with the onset age. There wereno correlation with disease’s severity and duration. There was a speculation that thedetermination of IGF-1, IGFBP-3level in serum could be used as indirect indicators ofbrain damage, but could not be used to assess the extent of brain damage; IGF-1,IGF-BP3in serum of women were apparently higher than that of male patients withmultiple system atrophy, so we speculated that estrogen could be involved in themetabolism of IGF-1and IGFBP-3.3. The level of serum insulin in multiple systematrophy had no obvious change. There were no significant correlation between Insulinlevels and the age of onset, sex, the subtypes of MSA, the course of disease and theUMSARS-Ⅱ scores.