| Objective To investigate the effect on the adult height (AH) of girls with onset ofpuberty at6or7years old.Methods AH was defined as either the bone age at the age of15years or older forgirls or at least3years after menarche. From1999to2010in our regions, relevantinformation of155girls with onset of puberty at6or7years old was collected successfullyby means of follow-up (The response rate in the follow-up was45.6%). Among thesepatients,92cases in accordance with the standards of AH were divided into three groups,untreatment group (39cases), traditional Chinese medicine (Dabuyin pill combinedwith Zhibai Dihuang pill) group (43cases) and gonadotropin releasing hormoneanalogue (GnRHa) group (10cases). AH of another69girls with normal puberty wereassigned to normal control group (the response rate in the follow-up was50.6%).Results The chronological age with onset of puberty (CA1), the chronologicalage at the beginning of the study (CA2) and the height at the beginning of the study intraditional Chinese medicine group and GnRHa group were [(7.01±0.60) yr vs (7.01±0.40) yr](P＞0.05),[(7.80±0.79) yr vs (8.38±0.43) yr](P＜0.05) and [(130.13±6.46) cm vs (134.93±3.36) cm](P＜0.05), respectively. The difference of CA1between untreatment group [(7.31±0.62) yr] and GnRHa group was extremely significant (P＜0.05), while there was no statistically significant difference ofCA2between untreatment group [(8.28±0.68) yr] and GnRHa group (P＞0.05). There was a statistically significant difference between untreatment group and traditional Chinese medicine group for CA1and CA2, and no significant differences can be found when comparing the ration of bone age≤16years or after menarche≤4years of two groups [76.9%(30/39) vs72.1%(31/43), P＞0.05]. The difference value (△BA-CA) of bone age minus the chronological age at the beginning of the study in untreatment group, traditional Chinese medicine group and GnRHa group were (2.04±0.69),(1.79±0.83) and (2. 44±0.76), respectively, P＞0.05; and the Z score (HtSDSCA) of height according tothe chronological age at the beginning of the study were (0.69±0.90)，(0.59±0.90) and(0.83±0.73), respectively, P＞0.05; and the Z score (HtSDSBA) of height according to bone ages were (-1.21±0.78),(-1.08±0.84) and (-1.12±0.80), respectively, P＞0.05; and the difference value (△AH-THt) between AH and target height were (1.63±4.04) cm,(2.84±4.37) cm and (3.83±4.31) cm, respectively, P＞0.05. The target height, AH and age of menarche in untreatment group, traditional Chinese medicine group, GnRHa group and normal control group were [(159.73±3.22) cm vs (158.46±4.37) cm vs (157.40±4.23) cm vs (158.33±4.02) cm](P＞0.05),[(161.36±4.64) cmvs (161.50±5.73) cm vs (161.23±5.05) cm vs (161.43±4.51) cm](P＞0.05),[(11.71±1.24) yr vs (11.46±0.91) yr vs (11.44±1.26) yr vs (12.13±1.38) yr](P＞0.05), respectively.Conclusion There is no significant effect on the AH with onset of puberty at6or7years old in our regions. And there is also no significant effect on the AH of girls withonset of puberty at6or7years old receiving Dabuyin pill combined with Zhibai Dihuangpill or GnRHa treatment in our regions. |
PDF Full Text Request