Analysis Of The Clinical Pathological Characteristics And Prognosis Of Breast Cancer In Young Women

Background: Breast cancer is one of the main malignant tumors harming the women’shealth all over the world. It is a main factor that leads patients to death in China. The newcases of breast cancer were210,000in China according to the latest statistics, the morbiditywas in the second place among the tumors and the first place among female malignanttumors. Although the incidence of breast cancer in young women (under35years old)accounts for about2.0%in all the patients, the incidence of breast cancer in young womencontinues to increase in some underdeveloped relatively countries. Young breast cancer ismore likely to relapse and metastasis, poor prognosis, which forms a threat to women’shealth. Studies have shown that young breast cancer has its own characteristics, this studyaims to discuss the clinical-pathological features and prognosis of young breast cancer andwhether it has its own characteristics, to provide a theoretical basis for clinical diagnosis andindividualized treatment.Objective: The aim of this study is to discuss the clinical-pathological characteristicsand prognosis of young breast cancer, and provide a reference for breast cancer diagnosisand individualized treatment options in young women.Methods: To analyze retrospectively the treatment methods and prognosis of1551patients with primary breast cancer from the breast surgery department of the first hospital ofJilin university from August2005to January2011. Divided the patients into two groups, theyoung group (under35years old,110cases) and the control group (36~75years old,1441cases). To explore the clinical and pathological characteristics, using the Kaplan Meier-survival curve drawing and the Log-Rank test method to compare disease-free survival (DFS)and overall survival (OS) between the two groups. Results：Young group accounted for7.1%in the same period, the primary lesionswere larger when they first visited (P=0.031); ER-positive expression ratio and Her-2-positive expression ratio were lower than those of the control group(62.7%,67.5%,P=0.001;26.4%,27.1%, P=0.768); ki-67high expression was higher than thatof the control group (45.5%,36.4%, P=0.072); There were no significant differencesbetween the two groups according to lymph node status, TNM stage, histological type,molecular subtyping (P>0.05); The operations of the two groups were given mostly withmodified radical (63.6%,76.1%), The proportions of the two groups with breast-conservingsurgery were28.2%and14.5%respectively (P=0.002). The postoperative local recurrencewithin5years in young group was higher than that of the control group (21.9%,3.5%,P=0.000), distant metastasis rate was10.4%and7.1%respectively, but there were nodifferences between them (P=0.242); The1,3,5-year disease-free survival (DFS) were91.2%,80.6%,67.7%and97.6%,92.1%,89.4%respectively between the two groups (χ2=10.334,P=0.001);1,3,5-year overall survival (OS) were100%,94.9%,89.1%and98.3%,93.2%,89.3%(χ2=0.373, P=0.542).Conclusion：The primary lesion is larger and ER-positive expression ratio is lower inyoung group; There is higher ratio of postoperative local recurrence in young women, but nosignificant difference in distant metastasis between the two groups; There is no difference inOS between them, but the DFS is poorer in young patients.