| Objective:Insomnia is a universal phenomenon in today’s fast andcompetitive society. Long-term insomnia brings huge negative effects onpeople’s life, work. Domestic research confirmed that patient’s insomnia withsleeplessness and anxiety-depression has direct correlation withanxiety-depression. Patients with the symptom of anxiety-depression whosemain complaint are insomnia can’t be neglected, and they should be diagnosedspecifically as early as possible, and be treated in time. Western medicine inthe treatment have a certain effect, but there are varying degrees of side effectsand withdrawal rebound phenomenon, reducing medication compliance. Theresearch of Chinese medicine to the Anxiety-related Insomnia has also madethe amazing progress, including the pathogeny and pathogenesis, dialecticalmedication, clinical observation and experimental research, unfolded thetraditional Chinese medicine(TCM) treating the sickness has certain potential.But due to the problem of Chinese medicine treatment working individuallyand slowly, the combination of TCM and Western medicine has attractedconsiderable attention. Anxiety-related Insomnia can be effectively treated byTCM and Western medicine of their respective advantages, paying attention tothe causes and symptoms and long-term effect, which is easy for patient toaccept. The topic aims at discussing the clinical efficacy of Jie-yu pillcombined with Mirtazapine pill to cure the Anxiety-related Insomnia, to start anew way of treating the sickness with combination of Chinese tradiational andWestern medicine.Methods:100cases of Anxiety-related Insomnia were randomly dividedinto control group (42cases) and treatment group (58cases) who were selectedfrom Neurology clinic outpatient and inpatient of the TCM hospital of HeBei. There was no significant difference of the two groups in age, gender, course ofdisease, anxiety scale, sleep quality. The control group was given onlymirtazapine30mg once per night, the treatment group took mirtazapinecapsules once, combined with Jie-yu pill4g (60grains), three times a day, bothgroups were served for8weeks. The treatment of depression outcome wereevaluated by HAMD assessment scale; the clinical depression efficacy werecalculated by the reduced rate of HAMD assessment scale; sleep quality wasevaluated by PSQI assessment scale; the clinical efficacy were calculated bythe reduced rate of PSQI assessment scale; The detection of blood routine tests,urine routine tests, liver biochemical tests, kidney function tests and ECG andadverse reaction were checked before and after the treatment.Results: Through the clinical observation showed that HAMD scorechanged before and after treatment, and compared with the control group, thetreatment group of HAMD score after treatment were more significantlyreduced（P＜0.01）; The treatment group of the HAMD score decreased after4weeks of treatment, compared with that before treatment, the differencewas statistically significant(p＜0.05); In the treatment of4weeks，HAMDscore of the control group was statistically significant(p＜0.05); by theHAMD reduced rate of clinical assessment， after8weeks oftreatment,treatment group of the total effective rate was84.48%, comparedwith that of control group69.05%，the difference was statistically significant.In the improvement of sleep quality，both groups was significantly reducedafter8weeks of treatment, the treatment group was better than the controlgroup(p＜0.01). In terms of the PSQI reduced rate after8weeks oftreatmeng,,treatment group of the total effective rate was79.31%, comparedwith that of control group69.04%，the difference was statistically significant.Blood and urine routine, liver and kidney function and ECG before and aftertreatment had no significant abnormalities. In adverse actions in c1inicalapplications，the observations showed that the treatment group had lesssignificant side effects. Conclusion: In the treatment of Anxiety-related Insomnia in stagnationof QI due to depression of the liver, uneasiness, Jie-yu pill combined withmirtazapine was better than mirtazapine used only in the improvement ofanxiety state and sleep quality, there was rapid effectiveness on set and fewside effects. |
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