Relationship Between CEACAM1Expression And Angiogenesis In Gastric Cancer

Objective To investigate the relationship between carcinoembryonicantigen-related cell adhesion molecule1（CEACAM1） expression and angiogenesis ingastric cancer.Methods CEACAM1and CD34expression was detected byimmunohistochemistry （IHC） in174cases of gastric cancer and40cases ofnonneoplastic gastric tissues.Results No CEACAM1expression was found in nonneoplastic gastric mucosatissues. CEACAM1expression was classified as high and low（69.0%vs.31.0）, theCD34-MVD expression between them was significantly different （57.32±6.56vs.44.26±7.25,P<0.05）. Coexpression of CEACAM1and CD34-MVD was elevated andsignificantly different from nonneoplastic to neoplastic lesions（P<0.05）. Moreover,high CEACAM1expression and CD34-MVD were closely associated with degree oftumor differentiation，nodal metastasis and TNM staging.Conclusions Up-regulating CEACAM1may participate in tumor angiogenesis,and promote its capability of invasion and metastasis.