Analysis Of The Related Influencing Factors Of Chronic Kidney Disease With Micro Inflammatory State

Background：In recent years，micro inflammatory state has caused people’s attention，as forchronic kidney disease (CKD) of the researches about pathogenesis and itscomplications. It a mild state that cause the increasing of cytokines and positiveprotein in blood circulation and can lead to some complications. It is a sign of microstate of inflamatory that CRP continue to rise in a low level,but no more than10-15mg/L. As for the improvement of the experimental methodology, high sensitive C-reactive protein (hs-CRP) can detect low level of CRP, and can react microinflammatory state in patients with CKD better.CRP of the healthy was less than3mg/L, when its more than3mg/L, even if no obvious clinical symptoms of infection,on behalf, there was pathologic reactive process of infection of the body. Microinflammatory state is common in patients with chronic kidney disease (CKD), thestate of inflammation is able to deteriorate the function of renal and lead tocomplications. Therefore, It is helpful to improve the patient’s quality of life andreduce the case fatality rate by making clear the mechanism of the microinflammatory for patients with chronic kidney disease (CKD), detecting andinterventing early.Object:To study the related influencing factors of chronic kidney disease with microinflammatory state.Method:Select the199patients from nephropathy Division of Jilin university in January2012to January2013for CKD. Divide the199paitients into two groups,accordingto the hypersensitive C-reactive protein (hs-CRP) values,one is a group with themicro inflammatory state,there were100paitients (hs–CRP is>3mg/L),and theother group without the micro inflammatory,there was99paitients (hs-CRP≤3mg/L)According to the conditions of the two groups of patients were analyzed, including age,sex,primary disease, blood pressure (BP), serum creatinine (Scr),glyceride (TG), cholesterol (TC), low density lipoprotein cholesterol (LDL-C),highdensity lipoprotein cholesterol (HDL-C), serum albumin (Alb), total protein(TP)etc.clinical data,biochemical parameters and left ventreicular ejection fraction(LVEF), left ventricular end-diastolic diamete（LVDd）, interventricular septalthickness(IVST). Normal or near normal distribution of measurements weredescribed as (x±s),the two samples were compared using independent samples t-test;Skewed distribution of measurement data were described Me(P25, P75), the sampleswere using Wilcoxon test.Each data was using linear correlation analysis (Pearsonrelated analysis), P＜0.05was statistically significant.Results:1.General clinical data: In199patients, male were112cases,female were87cases. Primary disease is primary glomerular disease, a total of97cases (45.73%),followed by diabetic nephropathy in83cases (27.64%), hypertensive nephropathy in37cases (18.59%), polycystic kidney disease in8patients (4.02%), chronicinterstitial nephritis in6cases(3.02%), obstructive nephropathy1cases(0.5%),others in1cases (0.5%). The time of dialysis of the patients with microinflammatoty state was longer than the patients without micro inflammatoty state（P＜0.05）. the primary disease，blood pressure difference was no statisticallysignificant (P＞0.05).2.Biochemical indicators, cardiac structure and cardiac function indicators:Scr,BUN,LVDd increased among the paitient with micro inflammatoty state, therewere statistically significantnt（P＜0.05）, Hb,Hct,TP,Alb, TC,LDL-C,EF decreasedamong the paitient with micro inflammatoty state, there were statistically significant（P＜0.05）. Between the cases without micro inflammatoty state and with microinflammatoty state pr-Alb, TG,,HDL-C, a ApoA indicators difference was nosignificant difference (P＞0.05). Between the two groups of IVST was no significantdifference (P＞0.05).3.Correlation: hs-CRP increased with Scr,BUN,LVSd were positively correlated, With Hb, Hct，TP,Alb,EF were negatively correlated（P＜0.05）.Conclusions:1. Among the patients with CKD,50.25%may have micro inflammatoy state,as the deterioration of kidney function,micro inflammatory state aggravate.the statemay, in turn, deteriorate the function of kidney.2. Micro inflammatory state may promote the development of complications ofthe anemia, malnutrition, cardiac failure.