A Clinical Study Of27Cases Of Cervical Metastatic Carcinoma Of Unknown Primary Site

Objectives: we retrospectively analyzed the clinical feature of cervicalmetastatic carcinoma of unknown primary site (CCUP) and investigatedthe therapy and prognosis of carcinoma of unknown primary site.According to the clinical classification, treatment, prognosis and so on,comprehensive elaboration the clinical biological behavior.Methods:27patients with CCUP were enrolled from May2007to September2013in second affiliated hospital of Jilin universitycollege of medical. Using spss19.0packages, with Kaplan-meiersurvival curve drawing method, use log-rank test to analyze statisticallysignificant, Cox proportional hazards regression model for multiplefactors analysis.Results: the proportion of male and female patients was1.4:1in thegroup of27cases of CCUP, male median survival was10months,while female was8months, Remove discrete values there was nosignificant difference between the survival tips sex with the log-rank test(p=0.691). In the group, the maximum age is75years old, the minimumage is34years old, the average age is58.3years old, the median survivalof patients who is younger than58.3years is10months, while the oldersis9months, there was no obvious difference in age with the log-rank test (p=0.331). Mass located in left neck in patients with a median survivalperiod for7months, patients in the right neck median survival was10months, the log-rank test suggests the mass position there was nosignificant difference of survival (p=0.513). Pathological types includessquamous cell carcinoma (48.1%), adenocarcinoma (22.2%), the Angle ofthe carcinoma (11.1%), small cell carcinoma (7.4%), anaplasticcarcinoma (3.7%), papillary carcinoma (3.7%), and gland scale cancer(3.7%), the majority was squamous cell carcinoma and adenocarcinoma.the median surial of patients who has squamous cell carcinoma is18months, the adenocarcinoma is7months, poorly differentiatednon-keratinizing carcinoma is17months. The log-rank test suggests thereare differences between the survival among pathological type (p=0.005).Found primary focal in the process of treatment is about11cases (40.7%).They come from nasopharyngeal (27.2%), lung (7.4%), throat (7.4%),hypopharynx (3.7%), tongue (3.7%), thyroid (3.7%), and ovary (3.7%).Eight cases with radiotherapy and surgical treatment, the median survivalperiod of them is10months.4cases treated with surgery，radiotherapyand chemotherapy, the median survival period is10months,4casestreated with surgery, the median survival period is3months,6cases ofconservative treatment, the median survival period is5months, The resultof the log-rank test among them is p=0.048. Cox regression analysisindicated that method of therapy (p=0.017) is predictive factor. Conclusions: the neck lymphatic drainage is rich, so its primary focalsources of CCUP can show diversity, Establishment of pathologicalclassification, primary focal earlier can improve prognosis. Takeappropriate treatment according to the pathological type can improveprognosis, in the relevant therapeutic scheme, combine treatment canprolong survival of patients.