A Clinical Study On The Relationship Between Febrile Convulsion And Iron Metabolism Or Other Serum Ions In Children

Objective：To probe the relationship between febrile convulsion and ironmetabolism, as well as other clinical risk factors, in order to provide clinicalguidance benefit for preventing and curing in childhood febrile convulsion.Methods： One hundred and sixteen subjects of childhood febrileconvulsion (FC) were recruited as observation group for this study. Thirty-eightgender and age matched children with upper respiratory infection presentingfever were used as control group. Serum iron (SI), ferritin (Fer) and total ironbinding capacity (TIBC) were measured, at the same time, hemoglobin (Hb),serum C-reactive protein (CRP), serum sodium (Na+) and serum microelements(Ca2+, Mg2+and Zn2+) were detected, to analyze whether these items wereclinical risk factors associated with FC development in children.Results: SI and TIBC of FC children were significantly lower than controlgroup (P<0.05); Fer concentration was apparently higher than control group(P<0.05); Serum Na+, Mg2+, Zn2+were markedly lower than control group(P<0.05). Multivariate Logistic regression analysis showed that SI, Fer andserum Na+might be risk factors for FC onset. There were no differences of Hband CRP levels between FC children and control group (P>0.05). Comparedwith simple FC, no differences had been found in complex FC in these clinicalfactors mentioned above (P>0.05). There was no close correlation between FConset and fever duration in these subjects (P>0.05). We divided FC children intotwo subgroups (age≤2years and age＞2years) according to age, there werestill no difference between these two subgroups (P>0.05).Conclusion：1. There is a close relationship between iron metabolism and FC pathogenesis in children, iron deficiency is a risk factor for FC development.2. Serum Na+concentration commonly decline in FC children, and thedecrement of serum Na+is also a crucial clinical risk factor for FC onset.3.Reduction of serum Mg2+or Zn2+is a phenomenon with high proportionoccurred in FC children. Our data indicated that it should be paid more attentionto monitor and correct iron metabolism and these serum ions in FC children inclinical work.