Study On The Continuous Trends Of Renal Function After Radical Nephrectomy

More than four decades, radical nephrectomy has been used as a standard treatmentfor kidney tumors and results in excellent tumor control. But with the time passed,researchers pay more and more attention to the changes in renal function on thecontralateral kidney, they have different conclusions on renal function of gradualimprovement or damage. Meanwhile, the influence of many other prognostic factors suchas diabetes, hypertension and age on renal function were unknown size, this study aims toanalyze the overall renal function recovery trends after radical nephrectomy in patients andquantitative analysis of the effects of different factors on the prognosis of renal function.objective: To evaluate continuous change in renal function by variousclinical factors after radical nephrectomy(RN) and investigate screening out high riskpatients of postoperative chronic kidney disease according to the different prognosticfactors, provide a reference for the development of clinical programs.Methods: Analysis of185cases of patients after radical nephrectomy throughcontinuous monitoring of postoperative serum creatinine. Using MDRD equation tocalculate eGFR. Linear mixed models were carried out to analyze postoperative continuouschange in eGFR in multivariate regression analysis postoperative risk factors for changesin renal function.Results:1. Overall, there was a subsequent restoration of renal function over thefollow-up period. The slope for the relationship between the eGFR and the time since RNwas0.099(95%confidence interval [CI]0.07-0.13; P <0.001) indicating that each monthafter RN was associated with an increase in eGFR of0.099mL·min-1·(1.73m2)-1·month-1.2. When we analyzed renal function based on various factors, postoperative eGFR of patients with diabetes mellitus, old age (>65years) was decreased or maintained at acertain level without any improvement in renal function.3. Preoperative predictors of anincrease in eGFR after RN were young age, no DM, no hypertension.Conclusion:1. Renal function recovered continuously during the six years follow-upperiod after RN.2. Renal functional recovery change were different according to variousclinical factors and such information should be taken into account when we determinedpatients’treatment for renal cell carcinoma (RCC).