The Expressions Of TK1and Ki-67in Bladder Urothelial Carcinoma And Their Correlation

Objective: To explore the expressions of thymidine kinase1(TK1) andnuclear-associated antigen67(Ki-67) in bladder urothelial carcinoma and theircorrelation and to determine whether TK1is a prognosis factor in bladdercancer.Methods: The pathological specimens of47cases of bladder urothelialcarcinoma and10cases of normal bladder from2010to2013were collected inthe Affiliated Cancer Hospital of Guangxi Medical University.Immunohistochemical SP method was used to detect TK1and Ki-67in all thespecimens．SPSS16.0was used to analyze the data: chi-square test was used tocompare the enumeration data and spearman was used to analyze the correlationanalysis．α=0.05was used to be the level of significance test and when P wasless than0.05，the difference was statistically significant.Results:1. The positive expression rates of TK1and Ki-67in bladderurothelial carcinoma were significantly higher than those of the normal bladder mucosa (P<0.05).2. The positive expression of TK1was related to the stage of bladderurothelial carcinoma (P <0.05); The positive expression of Ki-67was relatedto the stage and the pathological grade of bladder urothelial carcinoma (P <0.05).3. The expressions of TK1were positively correlated with Ki-67in bladderurothelial carcinoma (r=0.371，P=0.001)．Conclusion:1. The excessive expressions of TK1may be associated withthe excessive proliferation and bladder mucosa malignant transformation ofnormal bladder mucosa．2. This study shows that the higher expression of Ki-67occures in thepoorer pathological differentiation of bladder urothelial carcinoma tissues.3. TK1and Ki-67shows a correlation in their relationships with thestage of bladder urothelial carcinoma：the positive expression rates of TK1and Ki-67in muscle invasive bladder urothelial carcinoma are significantlyhigher than those of the non-muscle invasive bladder urothelial carcinoma(P<0.05).4. This study shows that the expression of TK1in bladder urothelialcarcinoma is related to the stage but the difference of the expression in thepathological grade is not statistically significant.Whether TK1is a prognosisfactor needs further study.