Protection Of Dietary Fiber Complex On Rat Intestinal Mucosal Barrier Of Acute Pancreatitis

Objective To explore dietary fiber complex (DFC) on acute pancreatitis (AP)’s mechanism of action of the intestinal mucosal barrier.Methods AP rat model was established with5%sodium taurocholate which was injected into pancreaticocholang retrogradely.44rats were randomly divided into four groups. Simple model group (group A), Enteral Nutrition group (group B), Nutrison+composite dietary fiber [soluble dietary fiber (SDF):insoluble dietary fiber (IDF)=1:3](Group C), Nutrison+composite dietary fiber [SDF:IDF=3:1](Group D). Respectively extracted blood samples of rats’portal vein and aorta abdominalis then compared expression of endotoxin and D-lactic acid in the blood serum of rats in each group during12h,24h,48h.Results The release of the group C and D in serum endotoxin and D-lactic acid is lower than in group A and group B (P<0.05).the release of the group B is lower than group A(P<0.05). the release of the group C is lower than group D, but the difference was not statistically significant(P>0.05).Conclusion DFC has a protective effect on gut barrier in rat with acute pancreatitis.