Huangqiguizhi Soup Prevention Of Deep Vein Thrombosis After Knee Replacement Clinical Research

Objective：Thorough the observation of Astragaulus and Cinnamon Twing Five ingradients Decoction on the effects of artificial knee arthroplasty patients blood，theology D–dimer Astragals Decoction of five drugs for the prevention of artificialknee joint replacement of deep vein thrombosis of the clinical efficacy，safety andmechanism.Methods：According to case selection criteria selected from the two Department ofbone in Traditional Chinese Medicine Hospital of Anhui province from September，2012to January2014.The50cases of total knee arthroplasty for the treatment of kneeosteoarthritis patients， lower extremity vascular color Doppler ultrasound dounderstand the venous alular function， lower limb usually patients before operation，blood theology and D–dimer parallel dimmer check. Operation were performed by thesame group of physicians， operation were performed in the120min，an epiduralanesthesia, the knee midline approach， using tourniquet，and time is not more than90min. Postoperative elastic bandage， raising the affected limb，for venous thrombosisknowledge education， encourage patients to early limb functional exercise. Thepatients were randomly divided into treatment group and control group，25cases in eachgroup，the treatment group on postoperative day first to two times a day take AstragalsDecoction of five drugs (30g，12g，Radix Astragals cassia twig， ginger， jujube，12g10g8g,， by the Anhui Provincial Hospital of traditional Chinese medicinepharmacy unified preparation)250ml，even for7d in control group，postoperative12hstarted oral Lee of Shaba10mg，1times a day. The two groups before and after theoperation of2D first，7d in blood theology and D–dimer examination, postoperative48h pull out the drainage tube， and record the drainage；postoperative line7d of lowerextremity vascular color Doppler ultrasound detection has no deep vein thrombosis.Processing method of control group and treatment group. The two groups of patientswith D-two dimmer, blood theology examination results were analyzed.The results1. The treatment group and the control group before random factors (gender, age, type of prosthesis, parts, hemorrheology，D–dimer) there was no significantdifference (P>0.05)；2. Two groups of patients with postoperative1D hemorrheologyindexes (whole blood viscosity， plasma viscosity， erythrocyte aggregation index，blood sedimentation， fibrinogen and D–dimer level higher than preoperative，thereare significant differences (P <0.01or P <0.05)， which confirmed after TKA surgeryin high coagulation state， two groups of postoperative1week was showed to learn allthe indexes below postoperative1day；3. The treatment group after1week， wholeblood viscosity， fibrinogen， plasma viscosity and blood sedimentation were lowerthan the preoperative, there are significant differences (P <0.01)； Red blood cellaggregation index compared with preoperative no significant difference (P>0.05). Thecontrol group after1week，blood sedimentation is lower than the preoperative，there issignificant difference (P <0.01)；Whole blood viscosity，erythrocyte aggregation indexcompared with preoperative no significant difference (P>0.05)； The plasma viscosityand fibrinogen is still higher than preoperative；4. The treatment group1comprehensivepostoperative blood viscosity， plasma viscosity， fibrinogen， blood sedimentation，compared with the control group after1week， also have significant difference (P <0.01or P <0.05)， the treatment group is better than the control group； Red blood cellaggregation index，no statistical difference (P>0.05).5. Postoperative treatment wayand the control group in total traffic， statistical difference (P>0.05)；6. Thecomparison of two groups the incidence of DVT no statistical difference.Conclusion:The Astragaulus and Cinnamon Twing Five in gradients Decoction hasgood effection on DVT prevention， which can significantly improve TKA highpostoperative blood coagulation state，effectively reduce the incidence of DVT afterTKA, and no obvious adverse reaction， huangqi guizhi wuwu tang take convenient,safe，effective， economic price，so it is worthy of clinical use of Chinese medicineprescriptions.