An Observation On Fluctuation Of CRP In Patients With CHD Undergoing Percutaneous Coronary Intervention And The Effect Of Chinese Herbs

Objective: To investigate the change of plasma C-reaction protein (CRP)in patient with coronary heart disease (CHD) undergoing percutaneouscoronary intervention(PCI) and evaluate the effect on CRP of Chineseherbs.Methods: 33 patients undergoing PCI were randomly assigned to treatgroup(n=18) (Chinese herbs plus western medication) and control group(n=15) (western medication only). Western medication includedantiplatelet agent, LMWH, ACEI, ARBs,β-blockers and statin. The levelsof CRP and cTnI were measured before, immediately after and 15 days afterPCI respectively. T test was used to check the statistic differencesbetween two groups.Results: The serum levels of CRP in both groups rised immediately afterPCI, whereas the levels of cTnI droped remarkably. A fall in the levelsof CRP and cTnI was observed in both groups 15 days after PCI, comparedwith that before PCI, but no statistic difference was found between twogroups (P=0.389).Conclusion: The levels of CRP increased immediately after PCI inpatients with CHD, and significantly reduced after 15 days treatment,but Chinese herbs plus western medication showed no advantage on westernmedication only at a limitation of 15 days.