Preparation And Antibacterial Properties And Biocompatibility Of Antimicrobial Sutures Can Study

The surgical general unabsorbed sutures have no inhibitory effect on bacterias, viruses and other similar organisms. Owing to the presence of bacteria, there will be different degree of fester, inflammation and other similar symptoms in the healing process of sutural incision. In consideration of antibacterial and biocompatibility features, as known, tradional antimicrobial has various drawbacks such as unstable, easy to be oxidated, easy to lose, consumptive and etc. Therefore, devolping carriers containing antimicrobial substances is necessary. The new technology for investigating antibacterial agents has been extensive attented by scientists at home and abroad.On the basis of a comprehensive analysis of existing literature, the silver solution as a precursor, sodium montmorillonite (MMT) and hollow mesoporous SiO2sphere as medical carriers were proposed in this thesis. The silver having antimicrobial properties was loaded over the carrier by cation-exchange method and equal volume impregnation method for the preparation of Ag-MMT antibacterial agents. Then the antimicrobial agent was supported on the suture by two times of dipping and two times of rolling method. After that, the antibacterial properties were achieved on the modififed suture. The stucture, morphology and composition of the antibacterial sutures were extensively investigated with SEM, XRD, and TG-DSC techniques. At the same time, the effect of reaction conditions on the antibacterial ability and biocompatibility of the suture was also studied. The main results are summarized as follows.(1) Montmorillonite loaded silver antibacterial agent was obtained by the cation-exchange using AgNO3as a precursor to exchange in the interlayer of montmorillonite. The effects of AgNO3concentration, the reaction time, and reaction temperatures on the antibacterial ability of sutures were extensively investigated. The optimum reaction conditions of the antimicrobial agent were obtained by optimizing the reaction conditions. Sutures obtained under the optimum reaction conditions were used for the calculations the amount of silver. Then, the blood compatibility and tissue compatibility for the optimal antibacterial suture substances were tested to verify the biocompatibility of the substances via materials of biological performance testing method. (2) Hollow mesoporous SiO2spheres were obtained by sol-gel approaching using carbon sphere as a template, TEOS as a precursor and CTAB as a mesoporous agent, respectively. Ag-SiO2antibacterial was prepared by impregnation method that contains hollow mesoporous SiO2sphere as medical carrier and in the same method(1), the amount of containing silver of AgNO3as a precursor,450℃, calcined4h. The effects of dosage of TEOS, concentration of CTAB, reaction time, pH and calcination temperature on the stucture and morphology of the product were studied.In the same time, the antibacterial suture was tested by antibacterial properties and biocompatibility...