MYMOP Finished Version Scale Development Evaluation And Its Preliminary Application In The Field Of Coronary Heart Disease

AIMS:This study is aimed to adapt Measure Yourself Medical Outcome Profile (MYMOP) into Chinese version. To assess the feasibility, reliability, validity, qualitative and quantitative evaluation of CMYMOP in the coronary heart disease (CHD) of traditional Chinese medicine (TCM) fields.METHODS:MYMOP2was adapted into CMYMOP by forward-backward-forward translationstrategy and equivalence evaluation. Demographic data, risk factors, CMYMOP andSF-12were collected from the syndrome of phlegm and blood stasis and syndromeof qi deficiency and blood stasis through the epidemiological investigation ofCHD angina pectoris in the twelve national first-class hospitals. Feasibility,reliability and validity were assessed by completion time, retest reliability,content validity and criteria validity, respectively. Qualitative andquantitative evaluation which were patients’ most painful symptoms, limitedactivities and medicine application, were used for assessing the applicationof CMYMOP in the CHD fields of TCM.RESULTS:1. Suitable translation of CMYMOP was developed.2. For the feasibility, the average finished time were7.16±4.35minutes(syndrome of phlegm and blood stasis) and6.04±4.14minutes(syndromeof qi deficiency and blood stasis) from the data of1479patients for the CHDangina pectoris. For the reliability, its retest reliability of scale score andeach item were greater than0.9. For the validity, it had good content validity.For the criterion validity, it was low correlation between CMYMOP scores ofsyndrome of qi deficiency and blood stasis and SF-12all dimensions(r<0.4). Itwas high correlation between CMYMOP scores of syndrome of phlegm and blood stasisand SF-12physical composite summary(PCS), physiological function (PF), body pain (BP), general health (GH) and so on(r>0.4).3.30%-50%patients accompanied by hypertension and hyperlipidemia.20%patientshad suffered from myocardial infarction (MI) and PCI operation. From the CMYMOPqualitative and quantitative evaluation from patients with CHD angina pectoris,chest tightness and chest pain were more common and most painful symptoms inthe patients’ life. For the limited activities, walking, shopping, tai chi andclimbing stairs were the most hopeful and unable to engage for the CHD patients.Most painful symptoms lasted more than1year for60%of the patients.70%ofpatients drug intervention, with western medicine preparations accounting formost, but many patients still choosed proprietary Chinese medicine (such asTongxinluo, compound Danshen dropping pill, etc.) for regular treatment. Morethan90%of patients couldn’t accept it because of reducing the dose.4. In terms of TCM syndrome, syndrome of phlegm and blood stasis was higher thansyndrome of qi deficiency and blood stasis in the morbidity of MI, hypertensionand hyperlipidemia(p=0.002,0.000、0.025<0.05).Syndrome of qi deficiency andblood stasis was more obvious than syndrome of phlegm and blood stasis in theqi deficiency symptoms of weakness and breathless (p<0.05).CONCLUSIONS:1. This study adopted the methods of forward-backward-forward translation andcultural equivalence assessment, which was appropriate for chinesization ofquestionnaire aboard.2. CMYMOP had good feasibility, reliability and validity. We will totally assessthe metrology index and major changes of clinical symptoms by the responsibilityand MID.3. CMYMOP was introduced into the CHD fields of TCM, which was appropriateinstrument for people-reported outcome.4. CMYMOP was difficult for distinguish syndrome of phlegm and blood stasis fromsyndrome of qi deficiency and blood stasis in the CHD angina pectoris. In future,we will emphasize to consolidate study of CMYMOP diagnosis and evaluation efficacy for TCM’s syndrome and symptom so as to provide a diagnosis andevaluation instrument for the TCM’s syndrome.