| Objective To study the pathogenesis of SLE,To analyze if the levels of interleukin17(IL-17) and interleukin23(IL-23) in the peripheral blood of patients with SLE is normal, and to investigate the clinical significance. Through the research for the treatment of patients with SLE is expected to be in the cell factor provide new direction.Method Tirty-three Chinese SLE patients. Twenty healthy Chinese volunteers were recruited as normal controls. IL-17and IL-23levels were assessed by enzyme-linked immunosorbent assay (ELISA). And, the clinical and laboratory data of the patients were collected in order to explor the relationship of IL-17and IL-23with clinical of SLE patients. The patients were divided into differents groups according to the SLE disease activity index (SLEDAI) score, renal involvement and anti-dsDNA and levels of complement.Results Compared with patients with inactive SLE and normal controls, the levels of plasma IL-17and IL-23inpatients with active SLE were significantly increased (p<0.01), and there showed, no statistic differences between patients with inactive SLE and normal controls. Compared with normal controls, the levels of plasma. IL-17and IL-23in patients with nephritis and patients without nephritis (p<0.01). No significant differences were observed for plasma IL-17and IL-23between the patients with positive anti-dsDNA antibody and patients with negative anti-dsDNA antibody. No significant differences were observed for plasma IL-17and IL-23between low levels of complements and normal levels of complements.Conclusion1.The levels of plasma IL-17and IL-23are signigicantly elevated in patients with active SLE. The results suggest that IL-17and IL-23may play a male role in the disease occurrence and development process.2.Nephritis or not in the plasma may play a small role in the levels of plasma IL-17and IL-23.3. Positive anti-dsDNA antibody or not and the levels of complements in the plasma may play a small role in the levels of plasma IL-17and IL-23. |
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