Clinical Research Clinical Diabetic Nephropathy Treated Three Yellow Kidney

A variety of acute diabetes, chronic complications of diabetes is the leading cause of death in patients, with diabetic nephropathy (Diabetic Nephropathy, DN) damaging. Advantage of the presence of Chinese medicine in the treatment of diabetic nephropathy, but the clinical evaluation of the efficacy of traditional Chinese medicine on the DN has not yet formed a unified standard, although some scholars have begun to establish medicine diabetic medicine efficacy evaluation system from mul ti-dimensional, but still long-term clinical validation to be widely recognized."Three yellow kidney particles" Professor Zhao Jinxi through long-term clinical practice, the identified physical, identifying diseases, Trinity Clinic model based on a combination of the dialectic the creation of the treatment of diabetic nephropathy experience side mainly by raw Astragalus, Anemarrhena, antlers tablets, angelica root, turmeric, cooked rhubarb, burdock, Salvia and other components. This study of DN patients with clinical stage pharmaceutical intervention evaluated the overall efficacy and safety of observation to determine the clinical efficacy of this new Chinese medicine formulations. A multi-center, stratified, randomized, clinical trial methodology positive drug parallel controlled, based on diet therapy, medicine glucose, blood pressure, regulate blood lipids and other conventional treatment, the treatment group received three yellow kidney medicine granules,1bag each time, bid; renal failure in the control group plus delay the progress of the drug, irbesartan tablets150mg, qd. As of writing this thesis period, the study included patients with clinical stage DN45cases, of which22male patients, female patients,23cases treated23patients and22control patients in the treatment group and the control group ratio is about1:1. Of the45patients enrolled were observed for a period of three months the efficacy observed include syndromes points, FBG, HbAlc,24h urinary protein excretion, renal glomerular filtration rate. Observed symptom scores compared to baseline values and qi deficiency, blood deficiency, yin deficiency, yang deficiency, blood stasis, dampness permit changes. Evaluation using a combination of multi-dimensional idea of syndromes,24-hour urinary protein excretion, renal function, safety indicators and endpoints evaluated.By integrating syndromes,24h urine protein, serum creatinine, GFR, HbAlc and other inter-group before and after treatment and compared using SPSS17.0software for statistical analysis. The results showed that the treatment group of23cases, including four cases markedly effective in17cases,2cases, the total effective rate was91.3%higher. Description Three yellow particles in the kidney of DN patients improving clinical syndromes points, there are obvious advantages. Syndromes determine statistical analysis showed three yellow granules kidney treatment with irbesartan treatment programs exist DN significant difference DN program syndromes and the treatment group than the control group.24h in reducing urinary protein excretion in the treatment group were compared before and after treatment, through a non-parametric test P=0.039, with a significant difference, markedly effective rate was26.08%, the effective rate of47.82%, total effective rate was73.91%; the control group before and after comparison shows that non-parametric test P=0.108, no significant difference, markedly effective rate was22.72%, the effective rate of27.27%, the total effective rate of50%. There are two groups by chi-square test to compare the efficiency, P=0.222, not statistically different. In summary, showed three yellow kidney particlescan effectively improve the patient’s clinical stage DN syndromes, reducing24-hour urinary protein excretion, is an effective method of Chinese medicine treatment of DN.