| Objective:By definition of the ancient (ancient) and modern (today) and comparing these two periods physicians treating paralysis disease prescription medication, summarize the medicine differences and analyze the disease treatment philosophy differences and its reason reflected by the medicine difference between ancient and modern; Based on the differences for the use of poisonous medicine which found in the literature, and drawing on the experience of the use of Aconitum in Tibetan medicine, research the proportion of compatibility in Terminalia reducing Aconitum’s toxic by using experimental methods, which provide reference for the safety use of toxic drugs to treat paralysis disease.Method:Literature Research Methods:To provide evidence for the selection of the prescription, the paper firstly clear the concept, the meaning and the corresponding relations with modern medicine in certain diseases of Pa disease. According to the prescription selection basis, prescriptions of ancient physicians and modern physicians in treating Pa disease was respectively taken collection and collation. Ancient physicians’prescriptions comes from the writings of physicians, which is selected from the various writings of the Tang Dynasty to the eve of1949physicians. Modern physicians’prescriptions come from "the essence of modern Chinese doctors Medical Records"(1-6sets) and the Pa disease prescription randomly collected from some Outpatients. To medicine contained for prescription, regulate such as Classification, Medicine Property, Meridian and the presence or absence of Toxicity according to "Science of Chinese Materia Medical", and count in accordance with the use of frequency.Experimental Research Methods:For the differences of using toxic drugs, learning the use of Tibetan medicine Aconitum compatibility with Terminalia attenuated experience, the research uses animal acute toxicity test method, with two-lead ECG frequent premature ventricular contractions of rat toxicity index, by using bio-signals MedLab acquisition system to detect the ECG in rats after administration, and recording the first time and the number of premature ventricular premature beats of ECG in rats in each group, through the comparison between the two groups occurred premature initial time to evaluate what proportion of the compatibility of Aconitum and Terminalia of decoctions has less toxic. Uses HPLC to determine the content of three kinds of ester alkaloids and three kinds of Diester in the compatibility of Aconitum and Terminalia decoction and analyze the relationship between Determination results and toxicity of decoction. Finally, comprehensively analyze the results of animal experiments and chemical experiments to determine in what proportion compatibility, Terminalia attenuation of Aconitum better.Result:1Statistical results:①There are534prescriptions collected from ancient physicians, which including374herbs and4996frequencies in total. Ancient Pa disease prescription commonly used drugs which using frequency is greater than every herb average using frequency (4996/374) are82herbs. There are422prescriptions collected from modern physicians, which including352herbs and5942frequencies in total. Modern Pa disease prescription commonly used drugs which using frequency is greater than every herb average using frequency (5942/352) are96herbs. The statistical comparison results of commonly herbs from prescriptions in treating Pa disease between ancient and modern are that:Herbs, which was selected by both ancient and modern physicians for the treatment of Pa disease are53in total, which little or do not appear in modern Pa disease prescriptions are29, which little or do not appear in ancient Pa disease prescriptions are43, including only appearing in outpatient prescription18herbs.2Comparison results:①The common features of prescription medication in treating Pa disease is that the compatibility between rheumatism medicine and blood circulation drugs which basing on Xin Xiang fluency divergent and Ku Zao Dredge removed rheumatism and made blood unobstructed, and qualitative it by heating the cold and cooling the hot, and cure the root of disease by targeting liver, kidney and spleen.②There are differences in frequency of common medicine between ancient and modern prescription, such as the ancient physicians to relieving drugs and rheumatism based medicine, modern medicine physicians to blood circulation and rheumatism based medicine; the total frequency of spleen medicine in ancient prescriptions is higher, but in modern prescription the total frequency liver medicine is higher; ancient physicians is higher than modern medicine in the overall using frequency of toxic medicine, but modern physicians use the toxic Asarum more; higher using frequency in ancient Chinese medicine has Poria, Fangfeng, Monkshood, Ephedra, Breit, Aconitum, Ginger and Fangji; higher using frequency in modern medicine has Licorice, Cassia twig, Astragalus, Peony, Clematis, Rehmannia, Peony, Mistletoe, Safflower and Salvia.③There are differences in constitution of information between ancient and modern prescription, such as in the composition of classes, the ancient physicians prescription drugs mostly use medicine of warm inside, rheumatism medicine, Huatanzhike asthma drugs and qi drug, and auxiliary use relieving drugs, diuresis Shenshi drugs and drug Pingganxifeng by attention to the temperature in the cold, as well as the role of Xin Wen relieving phlegm and pathogenic wind in Pa disease process; modern physicians prescription drugs mostly use clearing heat, blood of stasis drugs, rheumatism medicine, qi medicine, and auxiliary use yin tonic, yang medicine, relieving drugs, giving attention to Thanh Hoa heat evil, Xin Liang Xie table and bleeding in the Bi disease process impact, and treat Pa disease from inadequate of Liver and Kidney. In the composition of Chinese herbal medicine potency, the medication of ancient physicians is mostly warm, including thermal medicine, for warming inside and removing cold; while medication of modern physicians is mostly cold, including cool medicine, but no case of using thermal medicine, for Thanh Hoa heat evil. In the composition of medicine smell, the medication of ancient physicians is mostly pungent, bitter and sweet taste used secondly, the medication of modern physicians is mostly bitterness, sweet secondly, pungent least. In the composition of the Meridian, the medication of ancient physicians is mostly targeting liver, spleen and kidney secondly, while the medication of modern physicians is similarly targeting liver firstly, but the kidney and lung secondly, spleen medicine use less.3Animal experiment results:By analysizing the time data of the first occurrence of premature ventricular contractions in each group, preliminary results and Terminalia1:6attenuation compatibility of Aconitum Aconitum better.4Assay results:Six kinds the total alkaloid content in descending order are:Aconitum single fried> Aconitum Terminalia1:1> Aconitum Terminalia1:6> Aconitum Terminalial:3.Conclusion:The medication of Bi disease prescription between ancient and modern times have significantly different, the difference is mainly reflected in the two aspects of "total-medicine differences in using frequency" and "specific-medicine differences in the information constitutes", including the eight differences in the results. And these differences can reflect differences of disease treatment philosophy between ancient and modern times, mainly due to: changes in the background, making the patient in which social, natural environmental factors and mental, psychological factors produce a corresponding change.Especially to be noted that, the results of literature study in contrast of the use of toxic drugs suggest that the toxicity of traditional Chinese medicine research attenuated method for ensuring its safe use in clinical treatment of patients with a certain sense of paralysis, and Tibetan medicine Aconitum attenuated compatibility with Terminalia experience is something we learn and study. The results of animal experiments carried out based on this initial display Aconitum compatibility with Terminalia1:6ratio of attenuated the effect is better, the total content of alkaloids by six kinds of size can evaluate the degree of hydrolysis of the ester type double Aconitum alkaloids, the higher the degree of hydrolysis, the lower the toxicity, the highest Aconitum Terminalia compatibility with1:3ratio, degree of hydrolysis, Aconitum Terminalia degree of hydrolysis followed by1:6, thus considering the results of animal experiments and chemical experiments, Aconitum and Terminalia be compatible with the ratio of1:6were fried, attenuation for Aconitum better. |
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