Lifestyle Interventions Related Metabolic Indicators Of Metabolic Syndrome Clinical Observation

Backgrounds:The spectrum of disease is changing gradually worldwide since the21st century. As a result, the morbidity of acute infectious diseases decrease year by year, while the morbidity of chronic and non-infectious diseases increase year by year. MS, as a typical chronic metabolic disease, draws more and more attention recently. Globally, the morbidity of MS has reached13.61%, but in our country, the rate is14-18%. MS is character ized by the disorder of glucose, lip id, blood pressure and central obesity. Meanwhile, it is a risk factor of cardiovascular disease, which can cause a variety of heart, brain complications that can seriously damage one’s health. IDF recommended some measures for MS Patients in2005, such as calorie restriction, increasing the amount of exercise, changing diet and so on. With the development of social economy and the popularization of medical sense, more and more attentions could be surely paid to lifestyle intervention measures.Objective:By observing the impact that lifestyle intervention measures have on the MS-related index, to evaluate the effectiveness and safety of lifestyle intervention measures.Methods:we choose34patients which has been diagnosed MS between March2013and September2013in endocrinology outpatient department of Dongzhimen Hospital. Then we recommend them a simple lifestyle intervention project:①Education: Firstly, patients should learn to count the total calorie according to their weight, height, size and activity intensity. secondly, patients should master food exchanging method, sports exchanging table and motion attention.②Dietary intervention:Patients should make their diet with low GI, low salt, low fat but high fiber food. If one’s uric acid is high, he should keep low purine diet. What’s more, patients should avoid eating fried foods and high calorie diet. one should restrict daily total calorie to no more than6930KJ, salt intake to less than6g. In the heat distribution, Carbohydrate should account for about60%of the total calorie, while fat25%, protein15%. Saturated fatty acid diet should be controlled less than10%of the total heat. Finally, diet is divided into five meals, that is, breakfast, lunch, dinner and two added meals after breakfast and lunch. One should keep a regular schedule for the five meals, each meals accounts for roughly20%of daily total calories. Surely, one can regulate the distribution according to the clinical practice. However, he should meet two demands, for one thing, the calorie before lunch should be controlled less than35%of the total heat, for another, the calorie in dinner should be controlled less than30%of the total heat. Patients should eat2000ml mineral water daily.③Exercise intervention:Patients should walk30minutes (>2Km) after lunch every day, theyshould also choose15minutes other low or moderate intensity aerobic training according their hobbies. Moreover, one should keep the schedule for4-5days every week.④Quitting smoking and limiting alcohol intake. Patients should keep weekly alcohol consumption less than2alcohol units. Intervention periods:8weeks, we use clinical symptom score, PG,2h-PG,,BMI,WHR, SBP, DBP, TG, TC as indexes to appraise its effectiveness.Meanwhile, we use adverse reactions rate to appraise its safety. As a result, we try to evaluate lifestyle intervention measures ability to decrease some MS-related indexes more comprehensively and rationally.Results:①Compared with8weeks ago, Patients’TC reduced(P<0.05), TG reduced (P<0.05);②After the intervention, Patients’BMI reduced (P<0.05), while WHR didn’t decline obviously (P>0.05);③After the intervention, Patients’2hPG decreased significantly (P<0.01), PG reduced(P<0.05);④After the intervention, Patients’SBP reduced (P<0.05), DBP reduced (P<0.05);⑤After the intervention, Patients’UA reduced(P<0.05);⑥After the intervention, Patients’ clinical symptom scores decreased significantly (P<0.01);⑦No adverse reactions occurred during this observation.Conclusions:Lifestyle interventions such as diet, exercise project, quitting smoking and restrict alcohol intake can improve some MS-related symptoms, and reduce the level of BMI, PG,2h-PG, TG,TC, SBP,DBP,UA.This lifestyle intervention project can be proved as a safe measure.