Synthesis Process Research And Process Design Herbicide Metsulfuron Intermediate Pyrimidine Amine

Sulfonylurea herbicides is a highly potent herbicide with highly active, broad-sp ectrum, low-dose, low toxicity, high selectivity, and other advantages. In the product ion process of sulfonylurea herbicides, 2-amino-4,6-dimethoxy-pyrimidine synthesis i theimportant intermediation. 2-amino-4,6-dimethoxypyrimidine synthesis in economic benefits, environmentalprotection, application value, social influence and so on is dir ectly related to the production of sulfonylurea herbicides. According to this, the synt hesis of 2-amino-4,6-dimethoxypyrimidine has been wide concern pesticideenterprises and scientific research personnel.Comprehensive comparative analysis of the status quo at china and abroad pyri midine synthesis of amines, Through the patent literature queries, market research, te chnical feasibility studies, laboratory synthesis to ultimately determine the synthetic r oute and process conditions of this design.In the laboratory, based on the analysis of the existing process line, economic, environmental hazards, technological transformation process, the use of liquid vapor and other equipment for the laboratory synthesis products were characterized to dete rmine, and thus the production of temperature, time, solvents and other conditions w ere explored and optimized to determine the best reaction time, reaction temperature and solventAccording to an annual target, the design method using amplification design in dustrial design, according to the mass balance calculation of materials, materials and other physical parameters, On the basis of industry standard combined with the rel ated standards,to choose the material selection, type selection of the equipment.Condensers for hydrogen chloride, cyclization kettle and other equipment for he at balance, demonstration 5000 L jacketed kettle cyclization area can not meet the te chnical requirements, through its serpentine coil design to meet the design requireme nts for heatingAccording to relevant laws and regulations, combined with actual production ne eds pyrimidine amine, for 300 tons pyrimidine amine synthesis workshop layout, the whole layout of equipment both tidy and reasonable security also need easy to oper ate.with auto CAD software to complete the process 300 tons pyrimidinamine flowch arts, workshop plans, use PDsoft software to draw workshop with three-dimensional graph, equipment blanking chart, line chart ISOBrief analysis on financial and economic, environmental protection, protective m easures.New technology of toluene instead washing for the vacuum degassing hydroge nchloride not only reduce the use of toluene recovery cost but also reduce the staff manual labor and improve the working environment, so the cost ofdesignof the pro duction technology of pyrimidine amine older technology has significantly decreased;To production method for a pot production method step by step, improve the effici ency of the reaction, the yield increased significantly.