Synthesis Process Improvement Of(R)-carboxyl(phenyl) Methanesulfonate And The Modified Beta-lactam Antibiotic

In this thesis, A stable(R)- carboxyl(phenyl) methyl sulfonate were prepared by using the racemic 2-sulfonic acid as the starting material, after the chiral resolution, neutralization, salt formation and other steps. Then prepare the D-sulbenicillin sodium and Cefsulodin sodium by formed a mixed anhydride under mild condition. The purity is higher than the current standard. the structure was verified by high performance liquid chromatography, nuclear magnetic resonance,mass spectrometry and infrared spectrometer.In addition, the Sulbenicillin sodium and Cefsulodin sodium were prepared by freeze drying process.Due to the high cost of freeze drying equipment, high energy consumption,We have prepared the D-sulbenicillin sodium and Cefsulodin sodium by crystallization in this thesis. It provides a new way for the production of medicinal products. and the drug crystal form was characterized by X- diffraction.